不同影像诊断方法对卵巢癌腹膜转移诊断价值的系统评价  

Meta-analysis of the diagnostic value of different imaging methods for peritoneal metastasis of ovarian cancer

作　　者：黄世明 吴思雨 孙永锋[3] 尹亮 岳建兰 林志春 Huang Shiming;Wu Siyu;Sun Yongfeng;Yin Liang;Yue Jianlan;Lin Zhichun(Department of Nuclear Medicine,Characteristic Medical Center of PAP,Tianjin 300162;Department of Obstetrics and Gynecology,Characteristic Medical Center of PAP,Tianjin 300162;Department of Military Medicine and Special Disciplines,Beijing 100027,China.)

机构地区：[1]武警特色医学中心核医学科,天津300162 [2]武警特色医学中心妇产科,天津300162 [3]武警北京总队医院军事医学与特种学科,北京100027

出　　处：《中华介入放射学电子杂志》2021年第2期177-182,共6页Chinese Journal of Interventional Radiology：electronic edition

摘　　要：目的系统评价CT、MRI、PET/CT显像在卵巢癌腹膜转移的诊断价值。方法通过中文数据库及英文数据库,分别检索CT、MRI、PET/CT显像对原发性卵巢癌伴腹膜转移的诊断性临床试验,分别基于患者或病灶提取真阳性、假阳性、真阴性、假阴性等原始数据,通过软件Meta-Discl 1.4进行数据分析,分别合并计算CT、MRI、PET/CT显像诊断卵巢癌腹膜转移的敏感性(SEN)、特异性(SPE)、诊断比值比(DOR)。结果最终纳入16篇文献,系统评价结果显示,基于患者的分析结果中,CT显像对卵巢癌腹膜转移的SEN、SPE、DOR值分别为76%(95%CI:70%~82%)、82%(95%CI:77%~86%)、21.72(95%CI:4.74~99.40),MRI显像分别为93%(95%CI:83%~98%)、81%(95%CI:73%~87%)、73.95(95%CI:20.56~265.98),PET/CT显像分别为73%(95%CI:63%~82%)、92%(95%CI:84%~97%)、30.29(95%CI:3.95~232.55)。基于病灶的分析结果中,CT显像对卵巢癌腹膜转移的SEN、SPE、DOR值分别为72%(95%CI:71%~74%)、86%(95%CI:85%~87%)、16.66(95%CI:4.23~65.58),MRI显像分别为87%(95%CI:85%~90%)、91%(95%CI:88%~92%)、68.28(95%CI:40.40~115.40),PET/CT显像分别为63%(95%CI:60%~66%)、87%(95%CI:84%~90%)、14.38(95%CI:5.81~35.59)。结论MRI是敏感性最高且特异性较强的检查方法,也是评估卵巢癌腹膜转移的最佳显像方法。Objective To systematically evaluate the diagnostic value of CT,MRI,PET/CT imaging in peritoneal metastasis of ovarian cancer.Methods The Chinese and English databases were used to retrieve the diagnostic clinical trials of primary ovarian cancer with peritoneal metastasis on CT,MRI,PET/CT imaging.True positive,false positive,true negative,false negative and other raw data were extracted based on patients or lesions and were analyzed using the software Meta-Discl 1.4.The sensitivity(SEN),specificity(SPE)and diagnostic odds ratio(Diagnostic odds ratio,DOR)of CT,MRI and PET/CT imaging in the diagnosis of peritoneal metastasis of ovarian cancer were calculated.Results Sixteen articles were finally included.The results of the systematic review showed that in the analysis results based on patients,the SEN,SPE,and DOR values of CT imaging for peritoneal metastasis of ovarian cancer were 76%(95%CI:70%~82%),82%(95%CI:77%~86%),21.72(95%CI:4.74~99.40),those of MRI imaging were 93%(95%CI:83%~98%),81%(95%CI:73%~87%),73.95(95%CI:20.56~265.98),and those of PET/CT imaging were 73%(95%CI:63%~82%),92%(95%CI:84%~97%),30.29(95%CI:3.95~232.55).In the analysis results based on the lesions,the SEN,SPE and DOR values of CT imaging for peritoneal metastasis of ovarian cancer were 72%(95%CI:71%~74%),86%(95%CI:85%~87%)and 16.66(95%CI:4.23~65.58),those of MRI imaging were 87%(95%CI:85%~90%),91%(95%CI:88%~92%),68.28(95%CI:40.40~115.40),and those of PET/CT imaging were 63%(95%CI:60%~66%),87%(95%CI:84%~90%),14.38(95%CI:5.81~35.59).Conclusions MRI is the most sensitive and specific examination method and it is the best imaging method for evaluating peritoneal metastasis of ovarian cancer.

关 键 词：卵巢癌 腹膜转移 CT MRI PET/CT 

分 类 号：R737.31[医药卫生—肿瘤]