低氧预适应下DNA甲基化调控BDNF和TrkB受体的研究进展  

Advances in DNA methylation regulating BDNF and TrkB receptor under hypoxic preconditioning

作　　者：张世纪 付翁 谢雅彬 谢伟[1,2,3] 刘远 ZHANG Shi-ji;FU Weng;XIE Ya-bin;XIE Wei;LIU Yuan(Inner Mongolia Key Laboratory of Hypoxic Translational Medicine,Baotou Medical College,Baotou 014040,China;School of Medical Technology and Anesthesia,Baotou Medical College,Baotou 014040,China;Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;The Second Affiliated Hospital of Baotou Medical College,Baotou 014030,China)

机构地区：[1]包头医学院内蒙古自治区低氧转化医学重点实验室与神经科学研究所,内蒙古包头014040 [2]包头医学院医学技术与麻醉学院,内蒙古包头014040 [3]首都医科大学宣武医院低氧适应转化医学北京市重点实验室,北京100053 [4]包头医学院第二附属医院,内蒙古包头014030

出　　处：《中国病理生理杂志》2021年第5期951-955,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.31860307);内蒙古自然科学基金资助项目(No.2020MS08171);内蒙古自治区高等学校“青年科技英才支持计划”项目(No.NJYT-18-B26);内蒙古自治区高等学校科学研究重点项目(No.NJZZ19189)。

摘　　要：低氧预适应(hypoxic preconditioning,HPC)是指机体在经历一次或多次短暂、非致死性低氧刺激后,获得的对更严重甚至致死性低氧/缺血刺激的耐受性,被认为是机体抗低氧/缺血的一种内源性保护现象[1]。虽然HPC可以明显减轻组织、器官尤其是神经系统的低氧/缺血损伤并产生保护作用[2-3],但其分子机制还不甚清楚。Hypoxic preconditioning(HPC)is an endogenous protective process of cells by mobilizing protec-tive molecules against hypoxic stimulation,but its mechanism is still unclear.Brain-derived neurotrophic factor(BDNF)and its receptor tropomyosin-related kinase B(TrkB)are closely related to the physiological functions of nervous system,and play an important role in neuroprotection of HPC.Many studies have shown that DNA methylation may be one of the endogenous neuroprotective mechanisms of HPC.In addition,DNA methylation regulates the expression of BDNF and TrkB to participate in the occurrence and development of some neurological diseases.Therefore,this review takes DNA methylation as the starting point,focuses on the possible mechanisms of BDNF and TrkB expression under HPC,and dis-cusses the effects of HPC on DNA methylation to regulate BDNF and TrkB expression.

关 键 词：低氧预适应 DNA甲基化 脑源性神经营养因子 原肌球蛋白相关激酶B 

分 类 号：R741.02[医药卫生—神经病学与精神病学] R363[医药卫生—临床医学]