New insights into the cell-and tissue-specificity of glucocorticoid actions  

作　　者：Linda Quatrini Sophie Ugolini 

机构地区：[1]Department of Immunology,IRCCS Bambino GesùChildren’s Hospital,Rome,Italy [2]Aix Marseille Univ,CNRS,INSERM,Centre d’Immunologie de Marseille-Luminy,Marseille,France

出　　处：《Cellular & Molecular Immunology》2021年第2期269-278,共10页中国免疫学杂志（英文版）

基　　金：The SU laboratory received funding from the European Research Council(ERC)under the European Union’s Horizon 2020 Research and Innovation Program under grant agreement no.648768;the Agence Nationnale de la Recherche(ANR)(No.ANR-14-CE14-0009-01);the ARC foundation(No.PGA120140200817).The SU laboratory is also supported by institutional grants from INSERM,CNRS,Aix-Marseille University and Marseille-Immunopole to the CIML.L.Q.has received funding from AIRC and from the European Union’s Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie grant agreement no.800924.

摘　　要：Glucocorticoids(GCs)are endogenous hormones that are crucial for the homeostasis of the organism and adaptation to the external environment.Because of their anti-inflammatory effects,synthetic GCs are also extensively used in clinical practice.However,almost all cells in the body are sensitive to GC regulation.As a result,these mediators have pleiotropic effects,which may be undesirable or detrimental to human health.Here,we summarize the recent findings that contribute to deciphering the molecular mechanisms downstream of glucocorticoid receptor activation.We also discuss the complex role of GCs in infectious diseases such as sepsis and COVID-19,in which the balance between pathogen elimination and protection against excessive inflammation and immunopathology needs to be tightly regulated.An understanding of the cell type-and context-specific actions of GCs from the molecular to the organismal level would help to optimize their therapeutic use.

关 键 词：GLUCOCORTICOIDS inflammation immune response 

分 类 号：R392[医药卫生—免疫学]