抗艾滋病病毒药物相关性肝损伤的研究  

Research of anti-HIV drug-related liver injury

作　　者：张瑞 吴苑妮 韩晓旭 刘辉 王玉琪 李鑫 ZHANG Rui;WU Yuanni;HAN Xiaoxu;LIU Hui;WANG Yuqi;LI Xin(The Second Department of Integrated Traditional Chinese and Western Medicine,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China)

机构地区：[1]首都医科大学附属北京地坛医院中西医结合二科,北京100015

出　　处：《胃肠病学和肝病学杂志》2021年第5期490-495,共6页Chinese Journal of Gastroenterology and Hepatology

摘　　要：高效抗反转录病毒治疗大大降低了艾滋病机会性感染的发病率和艾滋病的病死率,已成为全世界控制艾滋病公认的有效方法。但由于抗反转录病毒药物需要长期甚至终身服用,对于造成部分HIV/AIDS患者短期或长期的肝损伤,临床主要表现为转氨酶升高或黄疸,甚至可造成部分患者抗病毒治疗中断、亚临床肝炎,或致死性肝衰竭,严重影响HIV/AIDS患者的生活质量,甚至危及生命。目前,高效抗反转录病毒治疗导致肝损伤的机理尚未完全清楚。本文对抗病毒药物的类型、可能造成肝损伤的机制、危险因素及其临床治疗作一概述。High-efficiency antiretroviral therapy has greatly reduced the incidence of AIDS opportunistic infections and the mortality rate of AIDS,and has become a recognized effective method for controlling AIDS worldwide.However,because antiretroviral drugs need to be taken for a long time or even for life,the clinical manifestations of short-term or long-term liver damage in some HIV/AIDS patients are mainly manifested as elevated transaminase or jaundice,which may even cause the interruption of antiretroviral treatment in some patients and substandard treatment,clinical hepatitis,or fatal liver failure,seriously affects the quality of life of HIV/AIDS patients,even life-threatening.At present,the mechanism of liver injury caused by highly effective antiretroviral therapy is not fully understood.This article reviewed the types of antiviral drugs,possible mechanisms of liver damage,risk factors and clinical treatments.

关 键 词：艾滋病病毒 抗反转录病毒药物 肝损伤 

分 类 号：R575[医药卫生—消化系统]