Protein N-myristoylation:functions and mechanisms in control of innate immunity  

作　　者：Bin Wang Tong Dai Wenhuan Sun Yujun Wei Jiang Ren Long Zhang Mengdi Zhang Fangfang Zhou 

机构地区：[1]Institute of Biology and Medical Science,Soochow University,Suzhou,Jiangsu 215123,China [2]Anhui Anlong Gene Technology Co.,Ltd,Hefei 230041,China [3]The Eighth Affiliated Hospital,Sun Yat-sen University,Guangdong 518033,China [4]MOE Key Laboratory of Biosystems Homeostasis&Protection and Innovation Center for Cell Signaling Network,Life Sciences Institute,Zhejiang University,Hangzhou,Zhejiang 310058,China

出　　处：《Cellular & Molecular Immunology》2021年第4期878-888,共11页中国免疫学杂志（英文版）

基　　金：supported by a special program from the Ministry o f Science and Technology of China(2016YFA0502500 to L.Z.);the Chinese National Natural Science Funds(U20A20393,82041009,31925013,31671457,and 91753139 to LZ.,31871405 and 31571460 to FZ.);Jiangsu National Science Foundation(BK20180043 and 19KJA550003 to F.Z.);the Zhejiang Natural Science Fund(LD19C070001 to L.Z.);the Key Project of University Natural Science Foundation of Jiangsu Province(19KJA550003);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：Protein N-myristoylation is an important fatty acylation catalyzed by N-myristoyltransferases(NMTs),which are ubiquitous enzymes in eukaryotes.Specifically,attachment of a myristoyl group is vital for proteins participating in various biological functions,including signal transduction,cellular localization,and oncogenesis.Recent studies have revealed unexpected mechanisms indicating that protein N-myristoylation is involved in host defense against microbial and viral infections.In this review,we describe the current understanding of protein N-myristoylation(mainly focusing on myristoyl switches)and summarize its crucial roles in regulating innate immune responses,including TLR4-dependent inflammatory responses and demyristoylation-induced innate immunosuppression during Shigella flexneri infection.Furthermore,we examine the role of myristoylation in viral assembly,intracellular host interactions,and viral spread during human immunodeficiency virus-1(HIV-1)infection.Deeper insight into the relationship between protein N-myristoylation and innate immunity might enable us to clarify the pathogenesis of certain infectious diseases and better harness protein N-myristoylation for new therapeutics.

关 键 词：N-MYRISTOYLATION Innate immunity Myristoyl switches INFECTION TLR4 Viral assembly 

分 类 号：R392[医药卫生—免疫学]