Rh-Catalyzed Kinetic Resolution-Based Enantioselective[4+2]-Cydoaddition-lsomerization of Allene-1,3-dienes  

作　　者：Anni Qin Qian Zhang Hui Qian Yulin Han Shengming Ma 

机构地区：[1]Research Center for Molecular Recognition ond Synthesis,Deportment of Chemistry,Fudan University,220 Handan Lu,Shanghai 200433,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling in,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2021年第3期559-565,共7页中国化学（英文版）

基　　金：the National Natural Science Founda-tion of China(Grant No.21690063 for S.Ma and Grant No.21801041 for H.Qian)is greatly appreciated.We thank Mr.Feng Jiang in this group for reproducing the results of(3aS,7aS,E)-3h,(3aS,7aS,E)-3I,and(3aR,7aR,E)-3n presented in this study.

摘　　要：Main observation and conclusion The first example of Rh-catalyzed kinetic resolution of 1,3-disubstituted allene-1,3-dienes involving intramolecular[4+2]-cycloaddition has been developed.Followed by C=C isomerization,the reaction finally afforded aza-[4.3.0]bicyclic compounds with a very high en-antio-and E-selectivity.The mechanism has been unveiled by careful control experiments.The synthetic potentials of highly enanti-oenriched bicyclic products have also been demonstrated.

关 键 词：RHODIUM CYCLOADDITION Kinetic resolution ALLENES ISOMERIZATION 

分 类 号：O62[理学—有机化学]