Access to Stereodefined Multifunctionalizedβ,γ-Unsaturated Ketones via Chemo,Regio-and Diastereoselective Copper-Catalyzed Diborylation of Cross-Conjugated Enynones  

作　　者：Shuai Zhang Xinhua Duan Pengfei Li 

机构地区：[1]Frontier Institute of Science and Technology,Xi'an Jiaotong University,Xi'an,Shaanxi 710054,China [2]School of Chemistry,Xi'an Jiaotong University,Xi'an,Shaanxi 710049,China [3]State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China [4]Xi'an Key Laboratory of Sustainable Energy Materials Chemistry,Xi'an Jiaotong University,Xi'an,Shaanxi 710049,China

出　　处：《Chinese Journal of Chemistry》2021年第3期590-596,共7页中国化学（英文版）

基　　金：the National Natural Sci-ence Foundation of China(Nos.21672168,21971202);the Key Laboratory Construction Program of Xi'an Municipal Bureau of Science and Technology(No.201805056ZD7CG40)。

摘　　要：Main observation and conclusion Stereodefinedβ,γ-unsaturated carbony|compounds are important yet synthetically challenging units in natural products and drugs.Disclosed herein is a mild,rapid copper-catalyzed diborylation reaction of cross-conjugated enynones as a step-economic and modular approach to stereodefined multifunctionalizedβ,γ-unsaturated ketones by fine control of chemo-,regio-,Z/E and diastereoselectivity.The substrate scope was examined and a possible catalytic cycle was proposed to explain the multifaceted selectivity.

关 键 词：STEREOSELECTIVITY β γ-Unsaturated ketones Copper catalysis BORYLATION Cross-conjugated enynones 

分 类 号：O62[理学—有机化学]