Aldolase is a sensor for both low and high glucose,linking to AMPK and mTORC1  

作　　者：Mengqi Li Chen-Song Zhang Jin-Wei Feng Xiaoyan Wei Cixiong Zhang Changchuan Xie Yaying Wu Simon A.Hawley Abdelmadjid Atrih Douglas J.Lamont Zhichao Wang Hai-Long Piao D.Grahame Hardie Sheng-Cai Lin 

机构地区：[1]State Key Laboratory for Cellular Stress Biology,School of Life Sciences,Xiamen University,Xiamen,Fujian,361102,China [2]Division of Cell Signalling and Immunology,College of Life Sciences,University of Dundee,DD15EH,Dundee,Scotland,UK [3]Fingerprints Proteomics Facility,School of Life Sciences,University of Dundee,DD15EH,Dundee,Scotland,UK [4]Department of Molecular&Cellular Endocrinology,Diabetes and Metabolism Research Institute,City of Hope Medical Center,Duarte,CA,91010,USA [5]CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,Liaoning,116023,China

出　　处：《Cell Research》2021年第4期478-481,共4页细胞研究（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(#91854208,#31922034,#32070753,#31730058,#2020J02003);the Fundamental Research Funds for the Central Universities(#20720200069);Shanghai Key Laboratory of Diabetes Mellitus(#SHKLD-KF-1703);the Project“111”sponsored by the State Bureau of Foreign Experts and Ministry of Education of China(#BP2018017);the XMU Training Program of Innovation and Entrepreneurship for Undergraduates(2019×0666)to S.-C.L.;by the Wellcome Trust(204766/Z/16/Z)to D.G.H.

摘　　要：Dear Editor,As well as glucose being the major carbon nutrient for most cells,its availability also acts as a gate-keeper exerting a switch between anabolic and catabolic metabolism,with the protein kinases mTORC1 and AMP-activated protein kinase(AMPK)being the two master controllers.1 In low glucose,AMPK is activated and phosphorylates a wide range of downstream targets to maintain energy homeostasis,by switching on catabolic pathways while switching off ATP-consuming processes.1 In high glucose,mTORC1 is activated and shifts the metabolic program of the cell towards anabolic metabolism.1 It is already known that low glucose,and hence low levels of the glycolytic intermediate fructose-1,6-bisphosphate(FBP),can be sensed by aldolase to trigger AMPK activation via the lysosomal pathway.2,3 This occurs independently of increases in AMP and ADP,the classical activators of AMPK.2 Although it is clear that mTORC1 is also regulated by glucose availability at multiple levels,the underlying mechanisms have not been fully elucidated.

关 键 词：METABOLISM mTORC1 HOMEOSTASIS 

分 类 号：R58[医药卫生—内分泌]