乳果糖联合双歧杆菌四联活菌片治疗老年慢性功能性便秘临床效果分析  

Clinical effect analysis of lactulose combined with bifidobacterium quadruple viable tablets in the treatment of chronic functional constipation in the elderly

作　　者：马卫涛 田密昌 张团结[1] 尹瑞[1] MA Weitao;TIAN Michang;ZHANG Tuanjie;YIN Rui(Department of Gastroenterology,Xihua People′s Hospital,Xihua County 466600,Zhoukou,Henan Province,China)

机构地区：[1]西华县人民医院消化科,河南省周口市西华县466600

出　　处：《内科》2021年第2期176-178,220,共4页Internal Medicine

摘　　要：目的探讨乳果糖联合双歧杆菌四联活菌片治疗老年慢性功能性便秘的临床效果,为临床治疗提供参考。方法选择2019年5月至2020年5月在本院门诊治疗的老年慢性功能性便秘患者100例作为研究对象,采用随机数字法分为两组,每组50例。对照组患者给予乳果糖治疗,研究组患者给予乳果糖联合双歧杆菌四联活菌片治疗,疗程1个月。比较两组患者的临床疗效;比较两组患者治疗前后的肛门直肠感觉变化情况及不良反应发生情况。结果研究组患者的治疗总有效率(96.0%)高于对照组(70.0%),差异有统计学意义(P<0.05)。治疗前,两组患者的肛门直肠感觉情况比较,差异无统计学意义(P>0.05);治疗1个月后,两组患者的直肠最低敏感量、直肠最大耐受量、直肠顺应性水平均显著降低,研究组患者的水平显著低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论乳果糖联合双歧杆菌四联活菌片治疗可明显提高老年慢性功能性便秘患者的临床治疗效果,改善肛门直肠感觉,缓解临床症状,值得推广运用。Objective To explore the clinical effect of lactulose combined with bifidobacterium quadruple viable tablets in the treatment of chronic functional constipation in the elderly,and to provide references for clinical treatment.Method A total of 100 elderly patients with chronic functional constipation who were treated in the Outpatient Clinic of our hospital from May 2019 to May 2020 were selected as the research objects,and they were divided into two groups by the random number method,with 50 cases in each group.The patients in the control group were treated with lactulose,and the patients in the study group were treated with lactulose combined with bifidobacterium quadruple viable tablets,for a one-month treatment course.The clinical efficacy was compared between the two groups.The changes of anorectal sensation before and after treatment and the occurrence of adverse reactions were also compared between the two groups.Results The total effective rate of treatment in the study group(96.0%)was higher than that in the control group(70.0%),and the difference was statistically significant(P<0.05).There was no statistically significant difference in the anorectal sensation before treatment between the two groups(P>0.05).After 1 month of treatment,the lowest sensitivity,maximum tolerated dose,and rectal compliance level of rectum significantly decreased in both groups,and the levels in the study group were significantly lower than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).Conclusion The treatment of lactulose combined with bifidobacterium quadruple viable tablets can significantly improve the clinical therapeutic effect of elderly patients with chronic functional constipation,improve anorectal sensation,and relieve clinical symptoms,which is worthy of promotion.

关 键 词：慢性功能性便秘 乳果糖 双歧杆菌四联活菌片 肛门直肠感觉 不良反应 

分 类 号：R574.62[医药卫生—消化系统]