狂犬病治疗方法及抗病毒药物应用的研究进展  

Research progress on rabies treatment methods and application of antiviral drugs

作　　者：刘茜 朱武洋[1,2] LIU Qian;ZHU Wu-yang(Key Laboratory of Biosafety,National Health and Family Planning Commission,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan 430000,China)

机构地区：[1]中国疾病预防控制中心病毒病预防控制所,国家卫健委生物安全重点实验室,北京102206 [2]中国科学院生物安全大科学中心,武汉430000

出　　处：《中国人兽共患病学报》2021年第5期444-449,共6页Chinese Journal of Zoonoses

基　　金：国家科技重大专项(No.2018ZX10201002,No.2018ZX10734401)。

摘　　要：狂犬病是由狂犬病病毒引起的,以侵犯中枢神经系统为主要特征的烈性人兽共患病,其病死率几乎100%。尽管及时、规范的暴露前和暴露后处置可以有效预防狂犬病,可是至今没有针对狂犬病的有效疗法及抗病毒药物。随着狂犬病病毒分子致病机制的深入研究,人们对狂犬病治疗方法及抗狂犬病病毒药物进行了一系列的探索。本文将对狂犬病治疗及抗病毒药物相关研究进展做一综述。Rabies is a severe zoonosis caused by rabies virus,which is mainly characterized by the invasion of the central nervous system.Its mortality rate is almost 100%.Although timely and standardized pre-exposure and post-exposure treatment can effectively prevent rabies,there are no effective treatments and antiviral drugs for rabies.With the in-depth study of molecular pathogenic mechanism of rabies virus,people have conducted a series of explorations on rabies treatment methods and anti-rabies virus drugs.This article reviews the advances on the rabies treatment and antiviral drugs.

关 键 词：狂犬病 狂犬病病毒 抗病毒药物 治疗 

分 类 号：R373.9[医药卫生—病原生物学]