应用PC MRI技术探讨老年性脑萎缩患者脑组织顺应性及流体动力学变化  

Application of PC MRI in the study of brain tissue compliance and hydrodynamic changes in elderly patients with cerebral atrophy

作　　者：邵演明 刘祝华 SHAO Yan-ming;LIU Zhu-hua(Baiyun District Maternal and Child Health Hospital,Guangzhou 510400,China)

机构地区：[1]广州市白云区妇幼保健院,510400

出　　处：《中国实用医药》2021年第14期1-6,共6页China Practical Medicine

基　　金：广州市白云区科技项目(项目编号:2018-YL034)。

摘　　要：目的运用相位对比磁共振成像技术(PC MRI)探讨老年性脑萎缩患者的脑部流体动力学模式及脑组织顺应性改变情况。方法选取42例老年性脑萎缩患者作为脑萎缩组,29例同时间段接诊的健康人作为对照组。两组均进行PC MRI检查,比较对照组、脑萎缩组双侧颈内动脉(ICA)、颈内静脉(IJV),基底动脉(BA)在心动周期内的收缩期达峰流速(PSV)、舒张期达峰流速(PDV)、平均流量(MF)、血管阻力指数(RI)水平,入颅总血流量、IJV引出血流量,中脑导水管(CA)、侧脑室(LV)的面积(Area)、PSV、PDV、MF水平,ICA、BA的“时相-流速曲线”,不同程度及不同年龄段脑萎缩患者左侧(L)-ICA、右侧(R)-ICA、BA、L-IJV、R-IJV的RI水平。结果脑萎缩组L-ICA、R-ICA、L-IJV、BA的PSV分别为(42.10±12.59)、(39.96±12.90)、(20.48±12.61)、(46.06±11.80)cm/s低于对照组的(49.93±11.41)、(50.97±12.25)、(28.24±12.19)、(55.03±6.78)cm/s;L-ICA、R-ICA、L-IJV、R-IJV、BA的PDV分别为(16.81±7.32)、(13.32±13.35)、(4.60±10.11)、(15.37±9.66)、(14.83±19.03)cm/s低于对照组的(22.95±7.45)、(23.72±8.14)、(13.28±8.42)、(22.47±12.69)、(26.15±5.80)cm/s;R-ICA的MF为(3.13±1.01)ml/s低于对照组的(3.93±0.94)ml/s;L-ICA、R-ICA、L-IJV、R-IJV、BA的RI分别为(2.22±0.99)、(2.23±1.35)、(5.10±7.23)、(2.52±1.20)、(2.17±1.99)高于对照组的(1.37±0.33)、(1.54±0.43)、(2.26±1.75)、(1.64±0.56)、(1.31±0.33),差异均具有统计学意义(P<0.05)。脑萎缩组入颅总血流量(8.59±2.15)ml/s低于对照组的(9.93±1.83)ml/s,差异具有统计学意义(P<0.05);对照组与脑萎缩组IJV引出血流量比较,差异无统计学意义(P>0.05)。脑萎缩组患者L-LV、R-LV的Area分别为(8.20±2.30)、(8.07±2.47)cm^(2)大于对照组的(4.69±1.00)、(4.45±1.53)cm^(2),CA的PSV为(4.40±1.12)cm/s、PDV为(3.67±1.17)cm/s低于对照组的(5.86±2.98)、(4.23±0.77)cm/s,CA、L-LV、R-LV的MF分别为(0.035±0.023)、(0.020±0.019)、(0.020±0.016)cm/s�Objective To discuss the application of phase-contrast(PC MRI)in the study of brain tissue compliance and hydrodynamic changes in elderly patients with cerebral atrophy.Methods There were 42 elderly patients with cerebral atrophy as cerebral atrophy group,and 29 healthy subjects as control group.PC MRI examinations were performed in both groups to compare peak systolic velocity(PSV),peak diastolic velocity(PDV),mean flow(MF)and vascular resistance index(RI)of bilateral internal carotid artery(ICA),internal jugular vein(IJV),and basilar artery(BA)in the cardiac cycle,total cerebral blood flow,IJV bleeding flow,area of cerebral aqueduct(CA)and lateral ventricle(LV)(Area),PSV,PDV,MF level,ICA and BA"phase-velocity curve"between the control group and cerebral atrophy group.RI levels of left(L)-ICA,right(R)-ICA,BA,L-IJV,R-IJV in patients with different degrees of brain atrophy and patients with brain atrophy at different ages.Results The PSV of L-ICA,R-ICA,L-IJV and BA of cerebral atrophy group were(42.10±12.59),(39.96±12.90),(20.48±12.61)and(46.06±11.80)cm/s,which were lower than(49.93±11.41),(50.97±12.25),(28.24±12.19)and(55.03±6.78)cm/s of the control group;the PDV of L-ICA,R-ICA,L-IJV,R-IJV and BA of cerebral atrophy group were(16.81±7.32),(13.32±13.35),(4.60±10.11),(15.37±9.66)and(14.83±19.03)cm/s,which were lower than(22.95±7.45),(23.72±8.14),(13.28±8.42),(22.47±12.69)and(26.15±5.80)cm/s of the control group;the MF of R-ICA of cerebral atrophy group was(3.13±1.01)ml/s,which was lower than(3.93±0.94)ml/s of the control group;the RI of L-ICA,R-ICA,L-IJV,R-IJV and BA of cerebral atrophy group were(2.22±0.99),(2.23±1.35),(5.10±7.23),(2.52±1.20)and(2.17±1.99),which were higher than(1.37±0.33),(1.54±0.43),(2.26±1.75),(1.64±0.56)and(1.31±0.33)of the control group.All the difference was statistically significant(P<0.05).The total cerebral blood flow(8.59±2.15)ml/s of cerebral atrophy group was lower than(9.93±1.83)ml/s of the control group,and the difference was statistically significant(

关 键 词：磁共振成像 相位对比 脑萎缩 流动模式 脑组织顺应性 

分 类 号：R741[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]