急性脑梗死再灌注治疗后的白细胞计数与疗效的相关性分析  

Correlation analysis of white blood cell count and curative effect after reperfusion treatment of acute cerebral infarction

作　　者：林俊明[1] 邓文斌[1] 乔娜 LIN Junming;DENG Wenbin;QIAO Na(Department of Emergency,Jiangmen Central Hospital,Jiangmen,Guangdong 529000,China)

机构地区：[1]江门市中心医院,广东江门529000

出　　处：《医药前沿》2021年第7期13-15,共3页Journal of Frontiers of Medicine

摘　　要：目的:探讨急性脑梗死(acute cerebral infrtion,ACI)患者接受早期再灌注治疗前后的外周血白细胞(peripheral white blood cell,WBC)计数与疗效、早期预后的相关性。方法:收集2019年6月—2020年6月在江门市中心医院急诊科就诊经绿色通道行早期再灌注治疗的ACI患者111例,记录病例行再灌注治疗前后的WBC计数,并探讨WBC计数与再灌注治疗前后美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分、灌注前后的NIHSS评分差以及出院时改良Rankin评分量表(modified rankin scale,MRS)评分的关系。结果:ACI患者早期再灌注治疗后WBC计数与再灌注治疗后NIHSS评分、MRS评分呈显著正相关(r=0.286,r=0.290,P均<0.01),与到诊时NIHSS评分呈正相关(r=0.215,P<0.05),与灌注前后NIHSS评分差呈负相关(r=-0.231,P<0.05),经介入治疗后的WBC水平比静脉溶栓治疗后的WBC水平高(P<0.01)。结论:ACI患者再灌注治疗后1天WBC水平可作为评估病情、疗效以及预后的参考指标。Objective To explore the value of peripheral blood leukocytes level and therapeutic effect,early prognosis in patients with acute cerebral infarction treated by early reperfusion therapy.Methods 111 cases of acute cerebral infarction receiving early reperfusion therapy were collected continuously.Peripheral blood leukocytes levels were measured before early reperfusion therapy and within 1 day after early reperfusion therapy In the past year(June 2019 to June 2020),respectively,to evaluate whether they were related to the changes of neurological function recorded as NIHSS score and mRS score.Results NIHSS score,MRS score were both significantly positive coorelated to peripheral blood leukocytes levels within 1 day after early reperfusion therapy in patients with acute cerebral infarction(r=0.286,r=0.290,P<0.01,respectively).The NIHSS score difference between before and after reperfusion therapy in patients was negative correlated to peripheral blood leukocytes levels after early reperfusion therapy(r=-0.231,P<0.05).The peripheral blood leukocytes levels after interventional therapy was higher than that after intravenous thrombolysis(P<0.01).Conclusion The peripheral blood leukocytes levels could be used as a predication indicator for early prognosis in patients with acute cerebral infarction.

关 键 词：外周血白细胞 急性脑梗死 再灌注治疗 

分 类 号：R743.3[医药卫生—神经病学与精神病学]