老年亚临床甲状腺功能减退患者非酒精性脂肪肝的相关研究  

Non-alcoholic Fatty Liver Disease in the Elderly with Subclinical Hypothyroidism

作　　者：陈哲[1] 缪琴 杨敏[1] 陈伟[1] 刘竟芳[1] Chen Zhe;Miao Qin;Yang Min;Chen Wei;Liu Jingfang(Changsha Central Hospital,Changsha 410004)

机构地区：[1]长沙市中心医院,长沙410004

出　　处：《国际老年医学杂志》2021年第3期167-169,共3页International Journal of Geriatrics

摘　　要：目的探讨老年亚临床甲状腺功能减退(SCH)患者非酒精性脂肪肝(NAFLD)的患病情况及相关性。方法选取长沙市中心医院118名SCH老年患者为SCH组,随机选取同期住院的120名甲状腺功能正常的老年患者为对照组。比较两组患者的血脂水平、NAFLD患病率及SCH组不同促甲状腺激素(TSH)水平患者NAFLD的患病率。结果SCH组NAFLD患病率明显高于对照组(P<0.05);随着TSH水平升高,NAFLD患病率呈上升趋势(P<0.05);SCH组血脂异常检出率明显高于对照组(P<0.05),表现为TC、TG、LDL-C水平的升高,差异有统计学意义(P<0.05),以TC升高最为明显。结论老年人SCH与NAFLD具有相关性,脂代谢紊乱可能在SCH患者NAFLD发生过程中占主导作用,但具体机制有待进一步研究。Objective To investigate the prevalence of non-alcoholic fatty liver disease(NAFLD)in older patients with subclinical hypothyroidism(SCH).Methods 118 older patients with SCH were assigned into SCH group in Changsha Central Hospital.120 older patients with normal thyroid function were assigned into control group.The level of serum lipids,the prevalence of NAFLD were compared between the two groups,and the prevalence of NAFLD was analyzed in patients with different level of thyroid stimulating hormone(TSH)in SCH group.Results The prevalence of NAFLD was higher in SCH group than that in control group(P<0.05).With the increase of TSH level,the prevalence of NAFLD increased(P<0.05).The detection rate of dyslipidemia in SCH group was significantly higher than that in control group(P<0.05),which was characterized with the elevated levels of TC,TG and LDL-C(P<0.05).Conclusion There is a correlation between SCH and NAFLD in older patients.Lipid metabolism disorder may play an important role in the development of NAFLD in patients with SCH.

关 键 词：亚临床甲状腺功能减退 非酒精性脂肪肝 老年 

分 类 号：R575.5[医药卫生—消化系统] R581.2[医药卫生—内科学]