肝硬化患者血清胃蛋白酶原、胃泌素17水平及其与病情的相关性分析  

Levels of serum pepsinogen and gastrin-17 in patients with liver cirrhosis and its correlation with the clinical manifestation

作　　者：丁平[1] 夏宏林[1] 王选举[1] DING Ping;XIA Hong-lin;WANG Xuan-ju(Department of Gastroenterology,Suzhou Municipal Hospital,234000 Suzhou,Anhui China)

机构地区：[1]安徽省宿州市立医院消化内科,安徽宿州234000

出　　处：《临床消化病杂志》2021年第2期117-120,共4页Chinese Journal of Clinical Gastroenterology

基　　金：安徽省对外科技合作计划项目(No:1908085QG309)。

摘　　要：[目的]探讨肝硬化患者血清胃蛋白酶原(PG)、胃泌素17(G-17)水平及其与病情的关系。[方法]选取确诊为肝硬化患者120例(观察组)。根据引起肝硬化发病的原因,分为病毒性肝炎肝硬化(观察1组,80例),酒精性肝硬化(观察2组,21例),代谢性肝硬化(观察3组,9例),肝静脉回流受阻性肝硬化(观察4组,10例)。按肝功能Child-Pugh分级标准,将120例肝硬化患者分为Child-Pugh A级34例,Child-Pugh B级50例,Child-Pugh C级36例。另选健康体检者60例为对照组。检测所有入选者空腹血清PGⅠ、PGⅡ和G-17水平并进行比较。用Pearson相关的方法分析血清PGⅠ、PGⅡ和G-17水平与肝硬化病变程度相关性。^(13)C呼气试验检测肝硬化患者幽门螺杆菌(Hp)感染情况。[结果]4个观察组血清PGⅠ、PGⅡ和G-17水平均高于对照组,PGR(PGⅠ/PGⅡ)水平均低于对照组(P<0.05);Child-Pugh C级、Child-Pugh B级患者血清PGⅠ、PGⅡ和G-17水平均高于Child-Pugh A级患者,PGR比值均低于Child-Pugh A级患者(P<0.05)。Child-Pugh C级患者血清PGⅠ,PGⅡ和G-17水平均高于Child-Pugh B级,PGR比值低于Child-Pugh B级患者(P<0.05);Pearson相关分析显示,血清PGⅠ、PGⅡ和G-17水平与肝硬化病变程度(Child-Pugh分级)均呈正相关(r=0.812、r=0.827和r=0.885,P<0.001);非Hp感染患者PGR水平高于Hp感染的患者(P<0.05),两者血清PGⅠ、PGⅡ和G-17水平比较,均差异无统计学意义(P>0.05)。[结论]肝硬化患者血清PGⅠ、PGⅡ和G-17水平升高,PGR水平降低;肝硬化分级越高,血清PGⅠ、PGⅡ和G-17水平越高,与肝硬化病变程度呈正相关;Hp感染对肝硬化血清PGⅠ、PGⅡ和G-17水平无明显影响。[Objective]To explore the levels of serum pepsinogen(PG)and gastrin-17(G-17)in patients with liver cirrhosis and its correlation with the clinical manifestation.[Methods]One hundred and twenty patients with liver cirrhosis diagnosed in our hospital were selected as subjects from January 2017 to August 2019.According to the causes of liver cirrhosis,viral hepatitis cirrhosis(n=80)were designed as observation group 1,alcoholic cirrhosis(n=21)were designed as observation group 2,metabolic cirrhosis(n=9)were designed as observation group 3,and hepatic venous reflux obstructed cirrhosis(n=10)were designed as observation group 4.According to the Child-Pugh classification criteria of liver function,120 patients with cirrhosis were divided into Child-Pugh class A(n=34),Child-Pugh class B(n=50),and Child-Pugh class C(n=36).The control group was 60 healthy subjects.Serum PGⅠ,PGⅡand G-17 levels were measured and compared in all patients with Liver cirrhosis and healthy subjects.Pearson correlation analysis of serum PGⅠ,PGⅡand G-17 levels correlates with cirrhosis lesions.The 13 C respiratory test was used to detect Helicobacter pylori(Hp)infection in patients with cirrhosis.[Results]The serum levels of PGⅠ,PGⅡand G-17 in the observation group were higher than those in the control group,and the levels of PGR were lower than that in the control group(P<0.05).The levels of PGⅠ,PGⅡand G-17 in the Child-Pugh class C and Child-Pugh class B were higher than those in the Child-Pugh class A,and the PGR was lower than that in the Child-Pugh class A(P<0.05).The serum PGⅠ,PGII and G-17 levels of Child-Pugh class C were higher than those of Child-Pugh class B,and the PGR was lower than that of Child-Pugh class B(P<0.05).Pearson correlation analysis showed that the serum PGⅠ,PGⅡand G-17 levels and degree of liver cirrhosis lesion were all positive correlation(Child-Pugh classification)(r=0.812,r=0.827,r=0.885,P<0.001);the PGR level of non Hp infected patients was higher than that of Hp infected patients(P<0.05).Two

关 键 词：肝硬化 胃蛋白酶原 胃泌素17 幽门螺杆菌 

分 类 号：R575.2[医药卫生—消化系统]