增龄相关性脑小血管病和特发性正常颅压脑积水共病导致的老年人认知和步态功能障碍三例临床分析  

Cognitive and gait dysfunction in the elderly caused by age-related cerebral small vessel disease and idiopathic normal pressure hydrocephalus:a case series of three patients

作　　者：何丹 谭双全[1] 蓝琳芳[1] 范玉华[1] He Dan;Tan Shuangquan;Lan Linfang;Fan Yuhua(Department of Neurology,the First Affiliated Hospital,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases,National Key Clinical Department and Key Discipline of Neurology,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院神经内科,广东省重大神经疾病诊治研究重点实验室,国家临床重点专科和国家重点学科,广州510080

出　　处：《中华医学杂志》2021年第15期1093-1096,共4页National Medical Journal of China

基　　金：国家重点研发计划(2016YFC1300600);广东省自然科学基金(2018A030313820);广州市科技计划(201803010067,202002030073)。

摘　　要：本研究回顾性总结中山大学附属第一医院神经科诊治的3例增龄相关性脑小血管病和特发性正常颅压脑积水共病案例,发现患者均表现为步态、认知及小便控制障碍。颅脑影像学提示脑小血管病及交通性脑积水。脑脊液Aβ42下降。APOE基因分型分别为ε3/ε4,ε3/ε3,ε2/ε3。给予全因个体化治疗后3例患者症状稳定或好转。Three cases with age-related cerebral small vessel disease and normal pressure hydrocephalus in the Department of Neurology of Sun Yat-sen University were retrospectively reviewed.All the patients exhibited gait disturbance,cognitive impairment and urinary incontinence.Meanwhile,the Craniocerebral imaging demonstrated cerebral small vessel disease and communicating hydrocephalus.The cerebralspinal fluid(CSF)Aβ42 levels decreased,and apolipoprotein E(APOE)genotypes wereε3/ε4,ε3/ε3,ε2/ε3,respectively.After treatment in an all-cause individualized manner,the symptoms of 3 patients were stable or improved.

关 键 词：脑小血管病 正常颅压脑积水 

分 类 号：R742.7[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]