肝细胞肝癌组织中硫氧还蛋白9表达水平与经肝动脉化疗栓塞术治疗疗效的关系  

The correlation between the expression level of thioredoxin domain containing protein 9 in hepatocellular carcinoma and the therapeutic effect of transcatheter arterial chemoembolization

作　　者：潘杨军 王耀[2] 章喜林 陆伟杰 郑银元[1] PAN Yangjun;WANG Yao;ZHANG Xilin;LU Weijie;ZHENG Yinyuan(Department of Radiology,Huzhou Municipal First People's Hospital,Huzhou,Zhejiang Province 313000,China)

机构地区：[1]湖州市第一人民医院放射科,浙江313000 [2]湖州市第一人民医院普外科,浙江313000 [3]湖州市第一人民医院中心实验室,浙江313000

出　　处：《介入放射学杂志》2021年第4期346-350,共5页Journal of Interventional Radiology

基　　金：浙江省医药卫生科技计划项目(WKJ2012-2-037)。

摘　　要：目的探究硫氧还蛋白9(TXNDC9)在肝细胞肝癌(HCC)组织中的表达及其与TACE治疗疗效的关系。方法选择2013年1月至2016年1月诊断为HCC的97例患者作为研究对象。用改良实体瘤疗效评价标准(mRECIST)评价TACE疗效。用免疫印迹法检测HCC组织中TXNDC9水平,并分析其与HCC患者TACE治疗疗效的关系。结果完全缓解(CR)组(17例)、部分缓解(PR)组(30例)、疾病稳定(SD)组(21例)和疾病进展(PD)组(29例)HCC组织中TXNDC9水平分别为(0.66±0.09)、(0.75±0.09)、(0.94±0.12)和(1.08±0.11),差异有统计学意义(P<0.05)。HCC组织中TXNDC9水平与TACE治疗疗效呈负相关(P<0.05)。TXNDC9诊断HCC预后的受试者工作特征(ROC)曲线下面积(AUC)、灵敏度和特异度分别为0.930、73.91%和96.08%。多因素Cox回归分析结果显示肿瘤直径、Child-Pugh分级和TXNDC9是HCC患者预后的独立影像因素(P<0.05)。结论HCC组织中TXNDC9水平高提示TACE治疗疗效较差,预后不良风险较高。Objective To investigate the correlation between the expression level of thioredoxin domain containing protein 9(TXNDC9)in hepatocellular carcinoma(HCC)tissues and the curative efficacy of transcatheter arterial chemoembolization(TACE).Methods A total of 97 patients diagnosed as HCC from January 2013 to January 2016 were selected as the subjects of this study.Modified response evaluation criteria in solid tumor(m RECIST)was used to evaluate the efficacy of TACE treatment.The level of TXNDC9 in HCC tissues was detected by Western blotting,and its relationship to the curative efficacy of TACE treatment in HCC patients was analyzed.Results The levels of TXNDC9 in HCC tissues of complete remission(CR)group(n=17),partial remission(PR)group(n=30),stable disease(SD)group(n=21)and progression disease(PD)group(n=29)were(0.66±0.09),(0.75±0.09),(0.94±0.12)and(1.08±0.11),respectively,and the differences were statistically significant(P<0.05).A negative correlation existed between the TXNDC9 level in HCC tissues and the curative effect of TACE treatment(P<0.05).The area under the receiver operating characteristic(ROC)curve,the sensitivity and the specificity of TXNDC9 in predicting HCC prognosis were 0.930,73.91%and 96.08%,respectively.Multivariate Cox regression analysis showed that tumor diameter,Child-Pugh classification and TXNDC9 level were the independent factors affecting prognosis in HCC patients(P<0.05).Conclusion A high level of TXNDC9 in HCC tissues indicates a poor curative effect of TACE and a high risk of poor prognosis.

关 键 词：肝细胞癌 经肝动脉化疗栓塞术 硫氧还蛋白9 疗效 预后 

分 类 号：R735.7[医药卫生—肿瘤]