小细胞肺癌预后因素研究进展  

Research Progress of Prognostic Factors of Small Cell Lung Cancer

作　　者：刘玲玲 高宏[2] 李夏平[2] LIU Lingling;GAO Hong;LI Xiaping(Liaoning University of traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《实用中医内科杂志》2021年第3期25-28,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：辽宁省中医药临床学(专)科能力建设(2017A01)。

摘　　要：小细胞肺癌(SCLC)的临床特点是低分化、高复发、高转移、预后差及生存期短。在西医方面,近年来非小细胞肺癌在靶向治疗及免疫治疗中都有突破性的进展,大大改善了非小细胞肺癌患者的生存期及预后效果;然而对比非小细胞肺癌,SCLC的治疗进展则相当缓慢,西医主要治疗手段为化疗及放疗,极少数患者可有手术的机会,与非小细胞肺癌突飞猛进的临床治疗成果相比SCLC则望其项背。在中医方面,中医并没有SCLC的概念,SCLC可归为咳嗽、咳血、肺积、虚劳等范畴,但临床上很少具体将SCLC细分化出来对其进行详细研究,SCLC的中医病因病机与治疗方面研究也比较少。目前,SCLC的发病机制并不明确而且对其治疗选择有限,但其预后与多种因素有关联。近年来对于SCLC预后因素的临床研究越来越多,大家都期望能在预后因素方面得到治疗SCLC的启发,从而提高患者生存期及生活质量。SCLC预后的因素也比较多,年龄、是否吸烟、PS评分、临床分期、临床指标、治疗手段等都是SCLC的预后因素。综合考虑这些预后因素对于临床上选择个体化治疗有着十分重要的意义;同时关注预后因素的变化可及时了解疾病的发展趋势并及早进行临床干预。就SCLC的临床分期、临床指标、中西医治疗与预后的关系加以总结,以期为临床提供更多思路。The clinical characteristics of small cell lung cancer(SCLC) are low differentiation,high recurrence,high metastasis,poor prognosis and short survival period.In western medicine,in recent years,non-small cell lung cancer has made breakthrough progress in targeted treatment and immunotherapy,greatly improving the survival and prognosis of non-small cell lung cancer patients;however,compared with non-small cell lung cancer,the progress of SCLC treatment is quite slow.The main treatment method of western medicine is chemotherapy and radiotherapy,very few patients can have the opportunity of surgery,and compared with the rapid progress of clinical treatment of non-small celllung cancer,SCLCis difficult to be treated.In traditional Chinese medicine,there is no concept of SCLC.SCLC can be classified into cough,hemoptysis,pulmonary accumulation,consumptive disease and other categories.However,in clinical practice,there is few specific differentiation of SCLC to carry out detailed research on it,and there is few research on the etiology,pathogenesis and treatment of SCLC in traditional Chinese medicine.At present,the pathogenesis of SCLC is not clear and the choice of treatment is limited,but its prognosis is related to many factors.In recent years,there are more and more clinical researches on prognostic factors of SCLC.We all hope to get the inspiration of treating SCLC in terms of prognostic factors,so as to improve the survival period and quality of life of patients.There are many prognostic factors in SCLC,such as age,smoking,PS score,clinical stage,clinical index and treatment.Comprehensive consideration of these prognostic factors is of great significance for the selection of individualized treatment in clinical practice.At the same time,paying attention to the changes of prognostic factors can timely understand the development trend of the disease and early clinical intervention.This paper summarized the clinical stages,clinical indicators,the relationship between the treatment of traditional Chinese and western

关 键 词：小细胞肺癌 虚劳 预后因素 临床治疗 研究进展 中西医 临床分期 临床指标 综述 

分 类 号：R734[医药卫生—肿瘤]