兽用抗菌增效剂制剂的研究进展  

Progress Research on Antibacterial Synergist Preparation for Animals

作　　者：黎欣 王志霞 潘源虎[1] 谢书宇[1] 袁宗辉[1] 黄玲利[1] 瞿玮 LI Xin;WANG Zhixia;PAN Yuanhu;XIE Shuyu;YUAN Zonghui;HUANG Lingli;QU Wei(MAO Key Laboratory for Detection of Veterinary Drug Residues,National Reference Laboraory of Veterinary Drug Residues,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]华中农业大学,国家兽药残留基准实验室,农业农村部兽药残留检测重点实验室,武汉430070

出　　处：《中国畜牧兽医》2021年第5期1816-1824,共9页China Animal Husbandry & Veterinary Medicine

基　　金：“十三五”国家重点研发计划(2017YFD0501402)。

摘　　要：抗菌增效剂属于人工合成的二氨基嘧啶类药物,此类药物与抗菌药物联合使用时会以特定的机制来增强抗菌药的药物活性。近年来,由于抗生素的广泛使用甚至滥用导致细菌耐药的问题日益显现,通过加入抗菌增效剂而研制出的新制剂可以提高抗菌药在动物体内的利用率、降低药物用量、增强药物疗效、降低兽药残留及减少细菌耐药性。文章分析了近年来甲氧苄啶、二甲氧苄啶和艾地普林与各类抗生素的联合使用制备的制剂产品,发现其对疾病的治疗效果普遍优于单独使用抗生素。同时,配合中药的使用对细菌耐药的问题有显著改善,为后期抗菌增效剂的研究打开新的局面。随着对兽药制剂的研究,其不再局限于简单的剂型,通过运用新技术、新材料研制出的制剂,针对不同的给药部位和给药途径可以对病患进行更精准的治疗,减少药物达到靶部位的时间,增加患病部位的药量,此思路可为后续的研发方向提供支持和参考。文章将对抗菌药-抗菌增效剂联用制剂的研发情况进行综述。Antibacterial synergist is a kind of synthetic diaminopyrimidine drugs.When these drugs are used in combination with antibacterial agents,they will strengthen the activity of antibacterial agents through a specific mechanism.In recent years,the problem of bacterial resistance has become increasingly apparent due to the widespread use and even abuse of antibiotics.New preparations developed by adding antibacterial synergists can improve the utilization rate of antibiotics in animals,reduce drug dosage,enhance drug efficacy,reduce veterinary drug residues and reduce bacterial resistance.The preparation products prepared by the combination of TMP,DVD and ADP with various antibiotics were analyzed in recent years.It is found that the therapeutic effect of these preparations is generally better than those antibiotics alone.Besides,with the use of traditional Chinese medicine,the problem of bacterial resistance has been significantly improved,which opens a new prospect for the research direction of antibacterial synergist in the later study.With the research of veterinary drug preparation,it is no longer limited to simple dosage forms.Through the use of new technologies and new materials,the preparation developed can provide more accurate treatment for patients according to different drug delivery sites and routes,reduce the time for drugs to reach the target site,and increase the dosage of patients.This idea can provide support and reference for the follow-up research and development direction.In this paper,the research and development of the combination of antibiotics and antibacterial synergists are reviewed.

关 键 词：抗菌增效剂 制剂 兽药残留 耐药性 

分 类 号：S859.5[农业科学—临床兽医学]