Association of a Tobacco-specific Nitrosamine Carcinogen with Urinary Cotinine,Urinary Sodium Excretion,and Total Energy Intake in Adolescents and Children  

作　　者：Jong Weon Choi Tatsuyoshi Fujii Noriyoshi Fujii 

机构地区：[1]Department of Laboratory Medicine,College of Medicine,Inha University,Incheon 22332,Republic of Korea [2]Deparment of Intermnal Medicine,Tsukuba University Hospital Mito Clinical Education and Training Center,Mito Kyodo General Hospital,Mito 310-0015,Japan [3]School of Medicine,School of Medicine and Medical Sciences,University of Tsukuba,Tsukuba 305-8577,Japan

出　　处：《Current Medical Science》2021年第2期270-278,共9页当代医学科学（英文）

基　　金：supported by a research grant from Inha University Hospital.

摘　　要：This study investigated the association of a tobacco-specific nitrosamine carcinogen,4-(methylnitrosamino)-1-(3-pyridy1)-I-butanol(NNAL)with urinary cotinine(uCot),urinary sodium(uNa)excretion,systolic blood pressure(sBP),and total energy intake in adolescents and children in relation to the subjects'age.A total of 790 subjects aged 6-19 years were evaluated.NNAL,uCot,corrected NNAL(cNNAL),the NNAL/uCot ratio,uNa,sBP,and nutrient intake were measured.A strong association between uCot and cNNAL was observed in children who were 11 years of age(r=0.881,P<0.001);however,no significant association was noted in adolescents who were 19 years of age.The uNa level was significantly higher(133.9 mmol/L vs.107.8 mmol/L,P<0.001)and sBP was significantly lower(105.3 mmHg vs.110.6 mmHg,P=0.012)in adolescents with elevated NNAL than in those without elevated NNAL.NNAL was significantly higher in subjects with increased uNa excretion than in those without increased uNa excretion.NNAL was positively correlated with uNa(r=0.183,P<0.001)and negatively correlated with sBP(r=0.142,P<0.001).Non-smokers with elevated NNAL/uCot ratios had significantly lower total energy intake than those without elevated NNAL/uCot ratios(1729.0 kcal/day vs.1911.0 kcal/day,P=0.008).The relationship between NNAL and uCot varied according to the subjects'age.NNAL seems to play a role in decreasing sBP by enhancing uNa excretion.Insufficient nutrient intake may contribute to endogenous formation of NNAL in non-smoking adolescents and children.

关 键 词：NITROSAMINE COTININE urinary sodium excretion nutrient intake blood pressure 

分 类 号：TS4[农业科学—烟草工业]