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Hidden allies:the role of gut microbes in carcinogen-driven cancer: 《Science China(Life Sciences)》2025年第4期1197-1198,共2页Ye Tian Hui Wang Hao Wu Jingyan Zhang; supported by the National Key R&D Program of China(2022YFA0806400,2021YFC2701100);National Natural Science Foundation of China(32271215)。; Both microbiota and carcinogens play crucial roles in tumorigenesis,yet the effect of microbes on carcinogen biotransformation remains poorly understood.Roje et al.(2024)provide new insights into microbe-carcinogen in...; 关键词：tumorigenesis intestinal microbiota bladder cancer n butyl n hydroxybutyl nitrosamine carcinogen biotransformation

Effects of nitrosamine impurities on the availability of Reference Listed drugs in China: 《Journal of Chinese Pharmaceutical Sciences》2025年第1期75-81,共7页Dongsheng Yang Jianzhao Niu Yufei Feng Nian Liu Lingyun Ma; Subject construction funding project of Institute for Chemical Drug Control(Grant No.2024HYZX42)in National Institutes for Food and Drug Control,Beijing,China。; The Reference Listed drug(RLD)plays a critical role in the development and research of generic medicinal products,serving as the comparator product used in the marketing authorization application of new generic medici...; 关键词：Reference Listed drugs Nitrosamine impurities Food and Drug Administration European Medicines Agency AVAILABILITY

Hepatoprotective effect of Holothuria leucospilota methanolic extract on dimethyl nitrosamine-induced hepatotoxicity in rats: 《Animal Models and Experimental Medicine》2024年第4期544-552,共9页Fatemeh Dejan Amineh Daneshi Javad Rajabi Aslani Nasrollah Ahmadi Narges Eskandari Roozbahani Elaham Rahmanian Reza Behmanesh Hamid Reza Gheisari; supported by Shiraz University,Shiraz,Iran; Background:Complementary medicine is an interesting field for extracting bio-active compounds from various plant and animal sources.The hepatoprotective effect of the methanolic extract of a species of sea cucumber ca...; 关键词：dimethyl nitrosamine HEPATOTOXICITY Holothuria leucospilota sea cucumber

Intake of tobacco nitrosamines of smokers in various provinces of China and their cancer risk:A meta-analysis: 《Journal of Environmental Sciences》2024年第7期249-260,共12页Xiao Li Zhiwei Ye Jun Wang Pengfei Lin Xiaojin Zhang Shuguang Xie Chao Chen; supported by the National Natural Science Foundation of China(No.22076091);the Key Technology Research and Development Program of Shandong(No.2020CXGC011406);the Natural Science Foundation of Beijing(No.8212029);the joint project of the State Key Joint Laboratory of Environmental Simulation and Pollution Control(No.21L01ESPC)。; Nitrosamines are a class of carcinogens which have been detected widely in food,water,some pharmaceuticals as well as tobacco.The objectives of this paper include reviewing the basic information on tobacco consumption...; 关键词：N-nitrosamine TOBACCO Cancer risk Tobacco specific nitrosamines(TSNAs) N-nitrosodimethylamine(NDMA)

Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review: 《Journal of Pharmaceutical Analysis》2024年第5期639-652,共14页Hemanth P.R.Vikram Tegginamath Pramod Kumar Gunjan Kumar Narasimha M.Beeraka Rajashree Deka Sheik Mohammed Suhail Sandeep Jat Namitha Bannimath Gayatiri Padmanabhan Ravandur S.Chandan Pramod Kumar Bannimath Gurupadayya; The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic effects.This systematic review investigates...; 关键词：CARCINOGENICITY GENOTOXICITY MUTAGENICITY Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related IMPURITIES

Clinical Relevance of Uric Tobacco-Specific Nitrosamine and Severe Abdominal Aortic Calcification in a National Survey of the United States: 《Cardiovascular Innovations and Applications》2023年第1期678-688,共11页Fang Wang Jingang Zheng; This work was funded by grants from the National Natural Science Foundation of China(number:81700411);National High Level Hospital Clinical Research Funding&Elite Medical Professionals Project of China-Japan Friendship Hospital(number:ZRJY2021-QM05);Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine(number:2021-QNRC2-A02);National Key Clinical Specialty Construction Project of China(number:2020-QTL-009).; Background:This cross-sectional study is the first investigation of the relationships among uric tobacco-specific nitrosamine(TSNA),N′-nitrosonornicotine(NNN),and abdominal aortic calcification(AAC)in adults in the U...; 关键词：Cigarette smoking Tobacco-specific nitrosamine N′-nitrosonornicotine Abdominal aortic calcification Cross-sectional study National Health and Nutrition Examination Survey

Effect of activated sludge treatment on the formation of N–nitrosamines under different chloramination conditions: 《Journal of Environmental Sciences》2022年第7期242-252,共11页Xiaolu Zhang Daekyun Kim Tanju Karanfil; Water Research Foundation (Project #4591) for their financial supports of this work。; Municipal wastewater discharge is considered as one of the main sources of N-nitrosamine precursors which can impact the qualities of downstream source waters and reclaimed wastewaters for potable reuse. N –Nitrosami...; 关键词：Disinfection by-products N–Nitrosamine formation potential Uniform formation condition(UFC) Sewage components Biological wastewater treatment

Electrochemical Reduction Determination of N-Nitrosodiphenylamine in Food Based on Graphene Electrode Material被引量：2: 《Journal of Donghua University(English Edition)》2022年第2期128-133,共6页XING Wenqian HU Jianmei ZHANG Xuan; Fundamental Research Funds for the Central Universities,China(No.2232020G-04)。; As a group of the most notorious carcinogens,N-nitrosamines(NAs)are highly toxic and usually involved in healthy issue of human daily life.An electrochemical sensor for N-nitrosodiphenylamine(NDPhA)detection was const...; 关键词：electrochemical sensor N-nitrosamine(NA) GRAPHENE food sample

Ultra-Sensitive LC-MS/MS Method for the Trace Level Quantification of Six Potential Genotoxic Nitrosamine Impurities in Telmisartan被引量：1: 《American Journal of Analytical Chemistry》2021年第6期227-240,共14页Kartheek Srinivas Chidella Vijaya Bharathi Dasari Jayashree Anireddy; Nitrosamine impurities are potentially genotoxic which are considered under cohort of concern as per ICH M7 guidelines and need to be controlled at trace levels during quantification in drug substances and drug produc...; 关键词：NITROSAMINE NDMA GENOTOXIC LC-MS/MS TELMISARTAN IMPURITIES

A Participant-assigned Interventional Research of Precesarean Internal Iliac Artery Balloon Catheterization for Managing Intraoperative Hemorrhage of Placenta Previa and Placenta Accreta Spectrum Disorders After Cesarean Section被引量：3: 《Current Medical Science》2021年第2期336-341,共6页Yao FAN Xun GONG Nan WANG Ke-tao MU Ling FENG Fu-yuan QIAO Su-hua CHEN Wan-jiang ZENG Hai-yi LIU Yuan-yuan WU Qiong ZHOU Yuan TIAN Qiang LI Yin XIE Fan-fan LI Meng-zhou HE Rajluxmee Beejadhursing Dong-rui DENG Xiao-yan XU; supported by grants from the NationalScience & Technology Pillar Program of China duringthe Twelfth Five-year Plan Period (No. 2014BAI05B05);the National Natural Science Foundation of China (No.81873843);the Foundation at Research Funds forthe Central Universities (No. 2017kfyXJJ102 and No.2019kfyXKJC053).; Placenta accreta spectrum disorder (PASD) and placenta previa (PP) are two of the mosthideous obstetric complications which are usually associated with a history of cesarean section(CS). Moreover, women with PASD, PP ...; 关键词：NITROSAMINE COTININE urinary sodium excretion nutrient intake blood pressure

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