Hidden allies:the role of gut microbes in carcinogen-driven cancer  

作　　者：Ye Tian Hui Wang Hao Wu Jingyan Zhang 

机构地区：[1]Shanghai Key Laboratory of Metabolic Remodeling and Health,Institute of Metabolism and Integrative Biology,Fudan University,Shanghai,200438,China [2]State Key Laboratory of Genetic Engineering,Fudan Microbiome Center,School of Life Sciences,and Human Phenome Institute,Fudan University,Shanghai,200438,China

出　　处：《Science China(Life Sciences)》2025年第4期1197-1198,共2页中国科学(生命科学英文版)

基　　金：supported by the National Key R&D Program of China(2022YFA0806400,2021YFC2701100);National Natural Science Foundation of China(32271215)。

摘　　要：Both microbiota and carcinogens play crucial roles in tumorigenesis,yet the effect of microbes on carcinogen biotransformation remains poorly understood.Roje et al.(2024)provide new insights into microbe-carcinogen interactions,demonstrating that intestinal microbiota drives bladder cancer development by modulating the metabolism of the carcinogen N-butyl-N-(4-hydroxybutyl)-nitrosamine(BBN).

关 键 词：tumorigenesis intestinal microbiota bladder cancer n butyl n hydroxybutyl nitrosamine carcinogen biotransformation 

分 类 号：R730.2[医药卫生—肿瘤]