去甲基化酶FTO在心血管疾病中的研究进展  

Research progress of demethylase FTO in cardiovascular diseases

作　　者：刘滴 李云曌 周刚 吴辉 LIU Di;LI Yunzhao;ZHOU Gang;WU Hui(Institute of Cardiovascular Disease,China Three Gorges University,Department of Cardiology,Yichang Central People's Hospital,Yichang 443003,China)

机构地区：[1]三峡大学心血管病研究所,三峡大学第一临床医学院心内科,宜昌443003

出　　处：《生命的化学》2021年第3期552-557,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81600234)。

摘　　要：脂肪和肥胖相关蛋白(fat mass and obesity-associated protein,FTO)是N6-甲基腺苷(m6A)调控系统中关键的去甲基化酶。既往研究发现,FTO可参与肥胖、糖尿病以及昼夜节律等增加心血管疾病的患病和发病风险。FTO在心肌梗死、心肌肥厚以及心力衰竭的发生发展中均具有重要调控作用,可能是治疗多种心血管疾病的潜在靶点。本文主要对FTO调控机制及其在多种心血管疾病中的研究进展进行综述。Fat and obesity-related protein(FTO)is key demethylases in the regulatory system of N6-methyladenosine(m6A).Previous studies have found that FTO can be involved in obesity,diabetes and circadian rhythm,etc.,increasing the risk of cardiovascular disease.Recent studies have shown that FTO has an important regulatory role in the occurrence and development of myocardial infarction,myocardial hypertrophy and heart failure,and may be a potential target for the treatment of various cardiovascular diseases.This paper mainly reviews the FTO regulation mechanism and the research progress in various cardiovascular diseases.

关 键 词：心血管疾病 m6A甲基化 FTO 心肌梗死 心肌肥厚 心衰 

分 类 号：R54[医药卫生—心血管疾病]