SCN4B/β4在鼻咽癌组织中的表达及意义  

Expression and significance of SCN4B/β4 in nasopharyngeal carcinoma tissue

作　　者：陶露 韦卓利 武世伍[2] 承泽农[2] 江浩[3] 项平[1] TAO Lu;WEI Zhuo-li;WU Shi-wu;CHENG Ze-nong;JIANG Hao;XIANG Ping(Central Laboratory,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China;Department of Pathology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China;Department of Radiotherapy,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第一附属医院中心实验室,安徽蚌埠233004 [2]蚌埠医学院第一附属医院病理科,安徽蚌埠233004 [3]蚌埠医学院第一附属医院放疗科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2021年第4期440-443,共4页Journal of Bengbu Medical College

基　　金：安徽省自然科学基金项目(1308085MH164)。

摘　　要：目的:探讨电压门控钠离子通道β4亚基(SCN4B/β4)在鼻咽癌组织中的表达,并分析其临床意义。方法:应用免疫组织化学ElivisionTM Plus法检测90例鼻咽癌病人鼻咽部活检标本和20份存档的石蜡包埋正常鼻咽黏膜组织(主要为鼻咽黏膜慢性炎)标本的SCN4B/β4表达情况,分析SCN4B/β4的阳性表达与鼻咽癌病人临床病理特征的关系。结果:鼻咽癌病人SCN4B/β4蛋白表达率低于正常鼻咽黏膜组织病人(P<0.01);SCN4B/β4蛋白表达在不同T分期、N分期、M分期、临床分期差异有统计学意义(P<0.05~P<0.01),T1~T2期、M0期、Ⅰ~Ⅱ期SCN4B/β4蛋白高表达率高于T3~T4分期、M1分期和Ⅲ~Ⅳ期,随N分期增加,SCN4B/β4蛋白高表达率下降;SCN4B/β4高表达5年生存率为85.2%,高于SCN4B/β4低表达的60.3%(P<0.05)。结论:鼻咽癌组织的SCN4B/β4蛋白高表达与淋巴结和远处转移呈负相关,SCN4B/β4高表达病人生存率较高。Objective:To explore the expression level of voltage-gated sodium channelβ4 subunit(SCN4B/β4)in nasopharyngeal carcinoma tissue,and analyze its clinical significance.Methods:The expression levels of SCN4B/β4 in 90 nasopharyngeal biopsy specimens from nasopharyngeal carcinoma patients and 20 archived paraffin-embedded normal nasopharyngeal mucosal tissues(mainly chronic inflammation of nasopharyngeal mucosa)were detected using the ElivisionTM Plus immunohistochemical method.The relationship between the positive expression of SCN4B/β4 and clinicopathological features in patients with nasopharyngeal carcinoma were analyzed.Results:The expression rate of SCN4B/β4 protein in nasopharyngeal carcinoma tissue was lower than that in normal nasopharyngeal mucosa(χ2=19.31,P<0.01).The differences of the expression levels of SCN4B/β4 protein in different T stage,N stage,M stage and clinical stage were statistically significant(P<0.05 to P<0.01),the expression rates of SCN4B/β4 protein in stageT1-T2,M0,Ⅰ-Ⅱwere higher than that in stage T3-T4,M1 andⅢ-Ⅳ,and the expression rate of SCN4B/β4 protein decreased with the increasing of N stage.The survival rate of patients with high SCN4B/β4 expression was 85.2%,the survival rate of patients with low SCN4B/β4 expression was 60.3%,and the 5-year overall survival rate in patients with high expression of SCN4B/β4 was higher than that in patients with low SCN4B/β4 expression(χ2=5.35,P<0.05).Conclusions:The expression level of SCN4B/β4 protein in nasopharyngeal carcinoma is negatively correlated with the lymph node and distant metastasis.The survival rate in patients with high SCN4B/β4 expression is higher.

关 键 词：鼻咽肿瘤 电压门控钠离子通道β4亚基 预后 

分 类 号：R739.63[医药卫生—肿瘤]