Ethnopharmacology,chemodiversity,and bioactivity of Cephalotaxus medicinal plants  

作　　者：HAO Da-Cheng HOU Xu-Dong GU Xiao-Jie XIAO Pei-Gen GE Guang-Bo 

机构地区：[1]Biotechnology Institute,School of Environment and Chemical Engineering,Dalian Jiaotong University,Dalian 116028,China [2]Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China [3]Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China

出　　处：《Chinese Journal of Natural Medicines》2021年第5期321-338,共18页中国天然药物（英文版）

基　　金：the Scientific Research Funds Project of Liaoning Education Department(JDL2019012);Natural Science Fund of Liaoning Province(20180550190).

摘　　要：Cephalotaxus is the only genus of Cephalotaxaceae family,and its natural resources are declining due to habitat fragmentation,excessive exploitation and destruction.In many areas of China,folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison,many of which are cancer.Not only among Han people,but also among minority ethnic groups,Cephalotaxus is used to treat various diseases,e.g.,cough,internal bleeding and cancer in Miao medicine,bruises,rheumatism and pain in Yao medicine,and ascariasis,hookworm disease,scrofula in She medicine,etc.Medicinal values of some Cephalotaxus species and compounds are acknowledged officially.However,there is a lack of comprehensive review summarizing the ethnomedicinal knowledge o f Cephalotaxus,relevant medicinal phytometabolites and their bioactivities.The research progresses in ethnopharmacology,chemodiversity,and bioactivities of Cephalotaxus medicinal plants are reviewed and commented here.Knowledge gaps are pinpointed and future research directions are suggested.Classic medicinal books,folk medicine books,herbal manuals and ethnomedicinal publications were reviewed for the genus Cephalotaxus(Sanjianshan in Chinese).The relevant data about ethnobotany,phytochemistry,and pharmacology were collected as comprehensively as possible from online databases including Scopus,NCBI PubMed,Bing Scholar,and China National Knowledge Infrastructure(CNKI).44 Cephalotaxus"',and the respective species name were used as keywords in database search.The obtained articles of the past six decades were collated and analyzed.Four Cephalotaxus species are listed in the official medicinal book in China.They are used as ethnomedicines by many ethnic groups such as Miao,Yao,Dong,She and Han.Inspirations are obtained from traditional applications,and Cephalotaxus phytometabolites are developed into anticancer reagents.Cephalotaxine-type alkaloids,homoerythrina-type alkaloids and homoharringtonine(HHT)are abundant in Cephalotaxus,e.g.,C.lanceolata,C.fortunei var.alpina,C.

关 键 词：Cephalotaxus ETHNOMEDICINE Chemodiversity ALKALOIDS Bioactivity PHARMACOLOGY 

分 类 号：R965[医药卫生—药理学]