Polymodal Functionality of C. elegans OLL Neurons in Mechanosensation and Thermosensation  

作　　者：Yuedan Fan Wenjuan Zou Jia Liu Umar Al-Sheikh Hankui Cheng Duo Duan Du Chen Siyan Liu Luyi Chen Jilei Xu Firdosh Ruhomutally Lijun Kang 

机构地区：[1]Department of Neurobiology and Department of Neurosurgery of the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310053,China [2]NHC and CAMS Key Laboratory of Medical Neurobiology,MOE Frontier Science Center for Brain Research and Brain-Machine Integration,School of Brain Science and Brain Medicine,Zhejiang University,Hangzhou 310053,China [3]Department of Gastroenterology,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China [4]Department of Human Sciences and Psychology,University of South Africa(UNISA),Pretoria 0003,South Africa

出　　处：《Neuroscience Bulletin》2021年第5期611-622,共12页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (31471023, 31771113, and 31800878);the China Postdoctoral Science Foundation (2020M671695, 2020T130592, 2019T120505, and 2018M640551)。

摘　　要：Sensory modalities are important for survival but the molecular mechanisms remain challenging due to the polymodal functionality of sensory neurons. Here, we report the C. elegans outer labial lateral(OLL) sensilla sensory neurons respond to touch and cold. Mechanosensation of OLL neurons resulted in cell-autonomous mechanically-evoked Ca~(2+) transients and rapidly-adapting mechanoreceptor currents with a very short latency.Mechanotransduction of OLL neurons might be carried by a novel Na~+ conductance channel, which is insensitive to amiloride. The bona fide mechano-gated Na~+ -selective degenerin/epithelial Na~+ channels, TRP-4, TMC, and Piezo proteins are not involved in this mechanosensation.Interestingly, OLL neurons also mediated cold but not warm responses in a cell-autonomous manner. We further showed that the cold response of OLL neurons is not mediated by the cold receptor TRPA-1 or the temperaturesensitive glutamate receptor GLR-3. Thus, we propose the polymodal functionality of OLL neurons in mechanosensation and cold sensation.

关 键 词：Polymodal sensory neuron MECHANOSENSATION Thermosensation Sodium channel Cold receptor OLL neurons 

分 类 号：R338[医药卫生—人体生理学]