The network pharmacology of the mechanism of the drug pair on the treatment of new coronavirus pneumonia offending lung health syndrome  

作　　者：Xing Ren Jing Yang Wan-Tong Zhang Rui Gao 

机构地区：[1]Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China [2]Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China

出　　处：《Journal of Hainan Medical University》2021年第9期1-5,共5页海南医学院学报（英文版）

基　　金：National key R&D project of Traditional Chinese medicine modernization(No.2019YFC1709300)。

摘　　要：Objective:To explore the main pathways and possible mechanisms of lonicera Japonica and forsythia in the treatment of COVID-19 using network pharmacology.Methods:The TCMSP database,GeneCards,Uniprot,DAVID and othe1databases and Cytoscape software were used to build an interaction network and analyze GO biological processes and KEGG metabolic pathways.Results:A total of 26 lonicera Japonica-forsythia drugs were used to treat COVID-19,mainly through multiple pathways such as cancer pathway,tuberculosis,influenza A,hepatitis B,TNF signaling pathway and HIF-1 signaling pathway Participate in the treatment of COVID-19.Conclusion:The working mechanism of action of lonicera Japonica-forsythia medicine on the treatment of COVID-19 mainly reflects the regulation of cell apoptosis and gene expression,inhibition of viral replication,bacteriostatic and immunomodulation,etc.,providing relevant theoretical basis for the clinical treatment of COVID-19.

关 键 词：Network pharmacology Lonicera japonica FORSYTHIA COVID-19 

分 类 号：R73[医药卫生—肿瘤]