非酒精性肝炎的严重程度与2型糖尿病的关系分析  

Correlation between the severity of nonalcoholic hepatitis and type 2 diabetes mellitus

作　　者：李毅[1] 郑燃[2] 徐先立[3] LI Yi;ZHENG Ran;XU Xian-li(Department of Internal Medicine,Shenyang Agricultural University,Shenyang 110866,China)

机构地区：[1]沈阳农业大学医院内科,110866 [2]沈阳农业大学医院妇产科,110866 [3]沈阳农业大学医院外科,110866

出　　处：《中国现代药物应用》2021年第10期41-44,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析非酒精性肝炎的严重程度与2型糖尿病的关系,为防控和诊疗疾病提供参考。方法162例2型糖尿病患者,根据是否合并非酒精性肝炎分为甲组(合并非酒精性肝炎,80例)和乙组(未合并非酒精性肝炎,82例)。对两组患者的体重、身高、腰围进行测量,并计算体质量指数(BMI),同时检测糖脂代谢、肝酶等指标。观察并比较两组患者检测指标及合并症、饮茶情况。结果乙组BMI、丙氨酸氨基转移酶(ALT)、γ谷氨酰转肽酶(GGT)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)及腰围水平均低于甲组,高低密度脂蛋白胆固醇(HDL-C)水平高于甲组,差异有统计学意义(P<0.05)。乙组合并代谢综合征(MS)、高血压、冠心病、中心性肥胖的比例分别为13.41%、19.51%、9.76%、14.63%,均明显低于甲组的51.25%、45.00%、22.50%、63.75%,饮茶比例63.41%明显高于甲组的20.00%,差异有统计学意义(P<0.05)。结论2型糖尿病合并非酒精性肝炎患者BMI、ALT、GGT、TG、TC、LDL-C、FPG、HbA1c及腰围均会增高,同时高血压、中心性肥胖、冠心病、MS增加了2型糖尿病并发非酒精性肝炎的风险,而饮茶习惯能够降低2型糖尿病患者并发非酒精性肝炎的几率,具有改善非酒精性肝炎严重程度的作用。Objective To analyze the correlation between the severity of nonalcoholic hepatitis and type 2 diabetes mellitus,so as ot provide reference for control and treatment of disease.Methods A total of 162 patients with type 2 diabetes mellitus were divided into group A(with non-alcoholic hepatitis,80 cases)and group B(without non-alcoholic hepatitis,82 cases)according to whether it is combined with non-alcoholic hepatitis.The weight,height and waist circumference of the two groups were measured,and the body mass index(BMI)was calculated.At the same time,the glucose and lipid metabolism and liver enzymes and other indicators were measured.The detection indicators and comorbidities,and tea drinking situation of the two groups were observed and compared.Results The BMI,alanine aminotransferase(ALT),γglutamyltranspeptidase(GGT),triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c)and waist circumference of group B were lower than those of group A,and high density lipoprotein cholesterol(HDL-C)was higher than that of group A.All the difference was statistically significant(P<0.05).The proportion of combined with metabolic syndrome(MS),hypertension,coronary heart disease and central obesity of group B were 13.41%,19.51%,9.76%and 14.63%,which were all obviously lower than 51.25%,45.00%,22.50%and 63.75%of group A,and percentage of tea drinking habits 63.41%was obviously higher than 20.00%of group A.All the difference was statistically significant(P<0.05).Conclusion BMI,ALT,GGT,TG,TC,LDL-C,FPG,HbA1c and waist circumference will increase during the period of type 2 diabetes mellitus with nonalcoholic hepatitis.Meanwhile,hypertension,central obesity,coronary heart disease and MS will increase the risk of non-alcoholic hepatitis in patients with type 2 diabetes mellitus.Tea drinking habits can reduce the chance of non-alcoholic hepatitis in patients with type 2 diabetes mellitus,and improve the severity of nonalcoholic hepatitis.

关 键 词：非酒精性肝炎 2型糖尿病 严重程度 

分 类 号：R575.1[医药卫生—消化系统] R587.1[医药卫生—内科学]