生酮饮食治疗阿尔茨海默病的研究进展  

Progress on ketogenic diet in treatment of Alzheimer disease

作　　者：顾文明[1] 胡卫红[1] Gu Wenming;Hu Weihong(The Eleventh Clinical Department,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 201108,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心临床十一科,201108

出　　处：《神经疾病与精神卫生》2021年第4期301-304,共4页Journal of Neuroscience and Mental Health

摘　　要：阿尔茨海默病(AD)是最常见的老年期痴呆,但至今仍病因未明,也缺乏有效的治疗手段。近年来有研究显示神经代谢问题可能是AD发生的根本原因,脑内葡萄糖低代谢是AD早期重要特征,而高脂肪、低碳水化合物的生酮饮食为解决这些代谢问题提供了可能。目前已有研究显示,在AD早期进行生酮饮食干预,可以改善认知,其机制可能与其改善能量代谢,降低病理标志物水平及神经毒性,调节肠道菌群等有关。现就相关进展作一综述。Alzheimer disease(AD)is the most common senile dementia,but the cause of the disease is still unclear,and lack of effective treatment.In recent years,studies have shown that neurometabolic problems may be the root cause of AD,and low glucose metabolism in the brain is an important feature of the early AD,while the ketogenic diet with high fat and low carbohydrate provides the possibility to solve these metabolic problems.Current studies have shown that ketogenic diet intervention in the early stage of AD can improve cognition,and its mechanism may be related to improving energy metabolism,reducing the level of pathological markers and neurotoxicity,and regulating intestinal flora.This paper gives a summary of the related progress.

关 键 词：阿尔茨海默病 痴呆 酮体类 生酮饮食 综述 

分 类 号：R749.16[医药卫生—神经病学与精神病学]