恶性胸膜间皮瘤新辅助化疗后胸膜厚度对预后的潜在预测价值  

Potential predictive value of pleural thickness after neoadjuvant chemotherapy for the prognosis of malignant pleural mesothelioma

作　　者：席卓娜 乔亚红[1] XI Zhuona;QIAO Yahong(Henan Provincial Chest Hospital,Henan Zhengzhou 450003,China.)

机构地区：[1]河南省胸科医院,河南郑州450003

出　　处：《现代肿瘤医学》2021年第12期2081-2084,共4页Journal of Modern Oncology

摘　　要：目的:探讨新辅助化疗后胸膜厚度对恶性胸膜间皮瘤预后的潜在预测价值。方法:选择2013年5月至2017年12月在我院接受新辅助化疗和手术治疗的患者作为研究对象,采用单因素和多因素分析患者新辅助化疗前最大胸膜厚度(pre-max)、新辅助化疗后最大胸膜厚度(post-max)、新辅助化疗前3个区pre-max之和(pre-sum)、新辅助化疗后3个区post-max之和(post-sum)与患者无复发生存期(RFS)和总生存期(OS)的相关性。结果:不同性别、年龄、pre-max、部位、PS评分、T分期、病理T分期患者mRFS相比较差异均无统计学意义(P>0.05),不同pre-sum、post-max、post-sum、组织学类型、mRECIST和淋巴结转移患者mRFS存在统计学差异(P<0.05);不同性别、pre-max、pre-sum、部位、T分期患者mOS相比较差异均无统计学意义(P>0.05),不同年龄、post-max、post-sum、PS评分、组织学类型、病理T分期、mRECIST、淋巴结转移患者mOS相比较差异存在统计学意义(P<0.05)。Cox风险模型结果显示,年龄≥65岁、组织类型为非上皮型、淋巴结转移阳性、post-sum≥13 mm是影响OS的风险因素(P<0.05)。结论:新辅助化疗后post-sum与RFS和OS显著相关,虽然本研究存在一定局限性,但为胸膜厚度与恶性胸膜间皮瘤预后的相关性研究做出有益的探讨。Objective:To explore the potential prognostic value of pleural thickness after neoadjuvant chemotherapy for malignant pleural mesothelioma.Methods:Patients who received neoadjuvant chemotherapy and surgery in our hospital from May 2013 to December 2017 were selected as the study subjects.Single factor and multiple factor analysis were used to analyze the correlation between the patients'maximum pleural thickness before neoadjuvant chemotherapy(pre-max),the maximum pleural thickness after neoadjuvant chemotherapy(post-max),the sum of the three pre-max areas before neoadjuvant chemotherapy(pre-sum),the sum of the three post-max areas after neoadjuvant chemotherapy(post-sum)and the patients'recurrence-free survival(RFS)and overall survival(OS).Results:There was no significant difference in mRFS among patients with gender,age,pre-max,location,PS score,T stage and pathological T stage(P>0.05).There were significant differences in mRFS among pre-sum,post-max,post-sum,histological type,mRECIST and lymph node metastasis patients(P<0.05).There was no significant difference in mOS among patients with gender,pre-max,pre-sum,location and T stage(P>0.05).There were statistically significant differences in mOS among age,post-max,post-sum,PS score,histological type,pathological T stage,mRECIST,and lymph node metastasis(P<0.05).Cox risk model showed that age≥65 years old,non-epithelial tissue type,positive lymph node metastasis,post-sum≥13 mm were the risk factors of OS(P<0.05).Conclusion:Post-sum is significantly correlated with RFS and OS after neoadjuvant chemotherapy.Although there are some limitations in this study,it is useful to study the correlation between pleural thickness and prognosis of malignant pleural mesothelioma.

关 键 词：恶性胸膜间皮瘤 新辅助化疗 胸膜厚度 临床预后 

分 类 号：R734.3[医药卫生—肿瘤]