超声造影检查对非酒精性脂肪肝患者肝微循环状况的评估价值  

Values of contrast-enhanced ultrasound in evaluating liver microcirculation in non-alcoholic fatty liver patients

作　　者：张驰 张旭胜 韩立明 Zhang Chi;Zhang Xu-sheng;Han Li-min(Department of Ultrasound Medicine,Pidu People's Hospital of Chengdu,Chengdu 611730,China)

机构地区：[1]郫都区人民医院超声医学科,四川成都611730

出　　处：《四川生理科学杂志》2021年第4期579-582,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨超声造影检查在非酒精性脂肪肝(Nonalcoholic Fatty Liver Disease,NAFLD)患者肝微循环状况评估中的价值。方法:选择2018年6月至2019年6月在我院就诊的42例NAFLD患者为观察组,另选同期行超声造影检查的42例健康志愿者为对照组。所有受试者均由同一组具5年以上临床经验的影像学医生采用IU22彩色多普勒超声诊断仪进行超声造影检测。根据造影增强结果用Qontrast软件绘制时间-强度曲线,计算曲线下面积、峰值强度、达峰时间、上升时间、斜率及人工时间参数,包括门静脉-肝静脉始增时间差、肝动脉-门静脉始增时间差及肝动脉-肝静脉始增时间差。结果:两组受试者曲线下面积及峰值强度差异无统计学意义(P>0.05),但观察组达峰时间、上升时间均小于对照组,斜率大于对照组(P<0.05)。观察组门静脉-肝静脉始增时间差、肝动脉-门静脉始增时间差及肝动脉-肝静脉始增时间差均较对照组更短(P<0.05)。不同严重程度NAFLD患者曲线下面积及峰值强度差异无统计学意义(P>0.05),达峰时间、上升时间及斜率均随NAFLD严重程度升高而升高(P<0.05)。不同严重NAFLD程度门静脉-肝静脉始增时间差、肝动脉-门静脉始增时间差、肝动脉-肝静脉始增时间差均随病情严重程度升高而下降(P<0.05)。结论:NAFLD患者超声造影检查达峰时间、上升时间、门静脉-肝静脉始增时间差、肝动脉-门静脉始增时间差及肝动脉-肝静脉始增时间差均小于健康人群,斜率高于正常人群,且上述指标均随病情严重程度增加而改变。Objective:To explore the values of contrast-enhanced ultrasound in the evaluation of liver microcirculation in patients with non-alcoholic fatty liver(NAFLD).Methods:A total of 42 NAFLD patients treated in our hospital from June 2018 to June 2019 were selected as the observation group,and 42 healthy volunteers underwent contrast-enhanced ultrasound and serological examination were selected as the control group.All subjects were examined by the same group of imaging doctors with more than 5 years of clinical experience using IU22 color Doppler ultrasound diagnostic apparatus.Qontrast software was used to draw a time-intensity curve based on the results of contrast enhancement,and the area under the curve,peak intensity,peak time,rise time,slope,and artificial time parameters including portal vein-hepatic vein initial increase time difference,Hepatic artery-portal vein initial increase time difference and hepatic artery-hepatic vein initial increase time difference and other parameters were calculated.Results:There was no significant difference in the area under the curve and peak intensity between the two groups of subjects(P>0.05),but the peak time and rise time of the observation group were shorter than those of the control group,and the slope of the observation group was greater than that of the control group(P<0.05).The time difference between portal vein-hepatic vein initial growth,hepatic artery-portal vein initial growth time and hepatic artery-hepatic vein initial growth time difference in the observation group were shorter than those in the control group(P<0.05).There was no significant difference in the area under the curve and the peak intensity of NAFLD patients with different severity(P>0.05).The peak time,rise time and slope increased with the increase of NAFLD severity(P<0.05).The time difference between portal vein-hepatic vein initial increase,hepatic artery-portal vein initial increase time,and hepatic artery-hepatic vein initial increase time difference of different severe NAFLD degrees decrease

关 键 词：超声造影 非酒精性脂肪肝 微循环状况 评估价值 

分 类 号：R57[医药卫生—消化系统]