温湿指数对精神分裂症急性发作的影响及个体特征的修饰作用  

Association of schizophrenia onset with exposure to outdoor thermal comfort:effect modification by individual characteristics

作　　者：赵德胜 鲍萍 程健[2] 王旭 方诗元 苏虹[2] ZHAO De-sheng;BAO Ping;CHENG Jian;WANG Xu;FANG Shi-yuan;SU Hong(Department of Medical Administration,the First Affiliated Hospital,University of Science and Technology of China,Hefei 230001,China;Department of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,Hefei 230032,China;Department of Research,Provincial Children′s Hospital,Hefei 230051,China)

机构地区：[1]中国科学技术大学附属第一医院医务处,合肥230001 [2]安徽医科大学公共卫生学院流行病与卫生统计学系,合肥230032 [3]安徽省儿童医院科研处,合肥230051

出　　处：《中华疾病控制杂志》2021年第4期460-465,共6页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(8177120532)。

摘　　要：目的探索高温湿指数暴露与精神分裂症急性发作之间的关系。方法收集2005年1月1日―2014年12月31日合肥每日气象和精神分裂症数据。使用分布滞后非线性模型(distributed lag non-linear model,DLNM)分析温湿指数对精神分裂症急性发作的影响。同时,探讨性别、年龄、婚姻状况和研究时期段对暴露效应所产生的修饰作用。结果高温湿指数与精神分裂症急性发作存在相关,在滞后第2天的效应最大(RR=1.031,95%CI:1.011~1.051,P<0.05)。按个体特征进行亚组分析时,发现年龄21~60岁、男性和已婚患者相对其他人群更易受到高温湿指数暴露的影响。此外,相比第1个五年(2005―2009年),第2个五年(2010―2014年)高温湿指数暴露的危害效应呈现下降趋势。结论高温湿指数是精神分裂症急性发作的危险因素,21~60岁、男性和已婚患者更易受到高温湿指数的影响。Objective To investigate the association between exposure to high humidex and the risk of schizophrenia onset.Methods Daily schizophrenia and meteorological data from 1 January 2005 to 31 December 2014 in Hefei,China,were collected.We quantified the relationship between humidex and schizophrenia onset using a distributed lag nonlinear model(DLNM).The effect modifications by gender,age,marital status and study periods were also examined.Results High humidex was significantly associated with schizophrenia onset,with the largest effect at two days lag(RR=1.031,95%CI:1.011-1.051,P<0.05).When conducting subgroup analyses by individuals characteristics,we found that patients aged 21-60 years,males and married patients were more vulnerable to high humidex than patients aged 0-20,≥60 years,females and unmarried patients,respectively.In addition,we also observed a clear decline in the effect of high humidex on schizophrenia from the first five years(2005-2009)to the second five years(2010-2014).Conclusion This study suggested that high humidex was a risk factor for schizophrenia onset,and patients aged 21-60 years,males and married patients were particularly vulnerable to the effect of high humidex.

关 键 词：温湿指数 精神分裂症 急性发作 

分 类 号：R741[医药卫生—神经病学与精神病学]