息肉状脉络膜血管病变中脉络膜异常改变的研究进展  

Progress of choroidal abnormal changes in polypoid choroidal vasculopathy

作　　者：董素 蒋博[1] 张中宇[1] 孙大卫[1] Dong Su;Jiang Bo;Zhang Zhongyu;Sun Dawei(Ophthalmology Department,the 2nd Affiliated Hospital of Harbin Medical University,Haebin 150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院眼科,150086

出　　处：《国际眼科纵览》2021年第2期98-102,共5页International Review of Ophthalmology

基　　金：国家自然科学基金(81171381)。

摘　　要：脉络膜组织结构及功能的完整对视网膜功能正常发挥起重要作用。息肉状脉络膜血管病变(polypoid choroidal vasculopathy,PCV)是一类以异常分支状血管网和血管网末端息肉状膨大为特征的视网膜脉络膜疾病。其属于肥厚型脉络膜疾病谱,谱系疾病之间可以发生转化并且存在特征性脉络膜改变:局灶性或弥漫性脉络膜增厚、脉络膜大血管层厚度所占比值增加、脉络膜血管通透性增高、继发性视网膜色素上皮功能障碍或新生血管形成。目前研究表明,脉络膜改变表现不同的PCV,在治疗反应和预后方面存在着差异。从脉络膜的角度重新认识PCV,有助·于判断预后、指导治疗。A structurally and functionally intact choroid tissue is vitally important for the retina function.Polypoidal choroidal vasculopathy(PCV)is a fundus disease characterized by choroidal anomalous branch vascular network(BVN)and polypoid expansion at the end of the vascular network.PCV is a pachychoroid disease.Conversions can occur between spectrum diseases,and there are characteristic choroidal changes between them:focal or diffuse choroidal thickening,increased proportion of choroidal macrovascular layer thickness,choroidal vascular hyperpermeability,secondary retinal pigment epithelial dysfunction or neovascular formation.Current studies have shown that PCV with different choroidal changes has differences in treatment response and prognosis.Re-understanding PCV from the perspective of choroid is helpful to judge prognosis and guide treatment.(Int Rev Ophthalmol,2021,45:98-102)

关 键 词：息肉状脉络膜血管病变 肥厚性脉络膜疾病 脉络膜厚度 

分 类 号：R773.4[医药卫生—眼科]