低龄儿童龋病相关的唾液生化指标研究  

Salivary biochemical indices related to early childhood caries

作　　者：张颖[1,2] 贾松菠[3] 李帆 李姗姗 张利娟[1,2] 谭凯璇 卢洁 杨芳[2] Zhang Ying;Jia Songbo;Li Fan;Li Shanshan;Zhang Lijuan;Tan Kaixuan;Lu Jie;Yang Fang(School of Stomatology,Qingdao University,Qingdao 266003,China;Stomatology Center,Qingdao Municipal Hospital,Qingdao 266071,China;Dept.of Stomatology,Tianjin Children’s Hospital,Tianjin 300074,China)

机构地区：[1]青岛大学口腔医学院,青岛266003 [2]青岛市市立医院口腔医学中心,青岛266071 [3]天津市儿童医院口腔科,天津300074

出　　处：《华西口腔医学杂志》2021年第3期300-305,共6页West China Journal of Stomatology

基　　金：国家自然科学基金面上项目(81670979)。

摘　　要：目的比较低龄儿童龋患者和健康者唾液生化指标的差异及其与龋病状态的关联,建立龋病诊断模型。方法选取4~6岁儿童共120名,分为2组:低龄儿童龋患者(C组)和健康儿童(H组)各60名,采集唾液样本,比较pH、总蛋白以及离子浓度的差异,分析唾液生化指标与龋病状态的相关性,并建立龋病诊断模型。结果C组NO3-浓度显著低于H组,而Cl^(-)、Br^(-)、NH_(4)^(+)、Mg^(2+)浓度显著高于H组(P<0.05);唾液NO3-浓度与患龋状态呈负相关,Br^(-)、Cl^(-)、NH_(4)^(+)浓度与患龋状态呈正相关(P<0.05)。利用唾液生化参数建立的龋病风险评估模型区分C组和H组的准确率可达85%以上。结论唾液pH、总蛋白和离子浓度有助于诊断和评估低龄儿童龋。Objective This study aimed to compare the salivary biochemical indices between caries-free individuals and those with early childhood caries(ECC),and construct a saliva-based caries diagnostic model by analyzing the correlation between salivary biochemical indices and caries severity.Methods A total of 120 children aged 4-6 years were selected and divided into two groups:individuals with ECC(C group,n=60)and healthy children(H group,n=60).Salivary samples were collected to compare the pH,total protein,and ion concentrations between the two groups.The correlation between the salivary biochemical indices and caries severity was examined,and an ECC diagnostic model was established.Results The NO3-concentration significantly decreased in the C group,whereas the Cl^(-),Br^(-),NH_(4)^(+),and Mg^(2+)concentrations significantly increased in the C group(P<0.05).In addition,the salivary caries severity had a significantly negative correlation with the NO_(3)^(-)concentration but had a positive correlation with Br^(-),Cl^(-),and NH4+concentrations(P<0.05).The ECC diagnostic model based on salivary biochemical indices could yield satisfactory results in terms of distinguishing the C and H groups with over 85%accuracy.Conclusion Salivary biochemical indices can contribute to the diagnosis and risk assessment of ECC.

关 键 词：低龄儿童龋 唾液 生化指标 关联性 诊断模型 

分 类 号：R781.1[医药卫生—口腔医学]