Rab蛋白在神经退行性疾病中作用的研究进展  

Research progress of Rab proteins in neurodegenerative diseases

作　　者：李云[1] 王雪[1] 谢俊霞[1] 宋宁[1] LI Yun;WANG Xue;XIE Jun-Xia;SONG Ning(Department of Physiology and Pathophysiology,School of Basic Medicine,Institute of Brain Science and Disease,Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学基础医学院生理学与病理生理学系,脑科学与疾病研究院,青岛266071

出　　处：《生理学报》2021年第2期315-328,共14页Acta Physiologica Sinica

基　　金：supported by a grant from the National Natural Science Foundation of China(No.31871049)。

摘　　要：Rab蛋白是Ras超家族成员,是一类小分子GTP结合蛋白。在大分子物质进入细胞的内吞途径和细胞器间的物质转运过程中,Rab蛋白通过招募其效应蛋白可作用于囊泡形成、转运、黏附和融合,是囊泡运输过程中的关键调节因素。Rab蛋白及其效应蛋白定位和功能的改变与多种疾病相关。本文就Rab蛋白的主要功能及其在帕金森病、阿尔茨海默病、亨廷顿病等神经退行性疾病发生与发展过程中的作用进行综述。As a member of the Ras superfamily,Rab proteins are small GTP-binding proteins.In the process of endocytosis of macromolecules and substances delivery between organelles,Rab proteins act on vesicle formation,transport,tethering and fusion by recruiting their effectors,therefore being key regulatory factors in vesicle trafficking.Disturbance of localizations and functions of Rab proteins and their effectors are involved in the pathogenesis of several diseases.This review focuses on the main functions of Rab proteins and their possible roles in the onset and progression of neurodegenerative diseases including Parkinson’s disease,Alzheimer’s disease,and Huntington’s disease.

关 键 词：RAB蛋白 神经退行性疾病 Α-突触核蛋白 Β-淀粉样蛋白 TAU蛋白 亨廷顿蛋白 

分 类 号：R338[医药卫生—人体生理学] Q42[医药卫生—基础医学]