前列腺素E_(2)与缺血性脑卒中  

Prostaglandin E_(2)and ischemic stroke

作　　者：张媛爽 李清华[1] 柯尊记 ZHANG Yuanshuang;LI Qinghua;KE Zunji(Guangxi Key Laboratory of Brain and Cognitive Neuroscience,Guilin Medical College,Guilin 541004,China;Institute of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Key Laboratory of Health Identification and Evaluation of Shanghai,Shanghai 201203,China)

机构地区：[1]桂林医学院广西脑与认知神经科学重点实验室,桂林541004 [2]上海中医药大学中西医结合研究院,上海市健康辨识与评估重点实验室,上海201203

出　　处：《生命的化学》2021年第4期625-632,共8页Chemistry of Life

基　　金：国家自然科学基金面上项目(31271142);国家自然科学基金青年项目(31701217)。

摘　　要：前列腺素E_(2)(prostaglandin E_(2),PGE_(2))是由花生四烯酸经环氧合酶途径代谢生成的前列腺素之一,PGE_(2)通过其4种受体亚型(EP_(1)、EP_(2)、EP_(3)和EP_(4))介导产生多种生理功能,同时是缺血性脑损伤中的重要炎症介质。而在缺血性脑卒中发病机制中,PGE_(2)激活不同受体亚型而发挥不同的作用。本文将从受体作用特点的角度对PGE_(2)在细胞凋亡、谷氨酸的兴奋性毒性及钙超载、血脑屏障损伤和免疫炎症等缺血性脑卒中发病机制中的作用进行总结,为缺血性脑卒中的治疗寻找新的靶点和策略。Prostaglandin E_(2)(PGE_(2))is one of the prostaglandins synthesized from arachidonic acid through the cyclocyte pathway.PGE_(2)mediates various physiological functions by the receptors of PGE_(2)(EP_(1),EP_(2),EP_(3)and EP_(4)),and it is also an important inflammatory mediator for ischemic brain injury.PGE_(2)plays different roles in the pathogenesis of ischemic stroke due to its different receptors.The effect of PGE_(2)in the pathogenesis of ischemic stroke,such as apoptosis,excitatory toxicity of glutamate and calcium overload,blood brain barrier damage,and immune inflammation,will be summarized from the perspective of receptor action characteristics,so as to provide a new target and direction for the treatment of ischemic stroke.

关 键 词：前列腺素E_(2) EP受体 缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]