泛素特异性蛋白酶在肿瘤发生发展中的作用  

The role of ubiquitin-specific peptidases in cancer development and progression

作　　者：申香玉 史磊 申远 SHEN Xiangyu;SHI Lei;SHEN Yuan(Department of Chinese Materia Medica,School of Pharmacy,Xinxiang Medical University,Xinxiang 453003,China;Department of Biochemistry and Molecular Biology,School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,China)

机构地区：[1]新乡医学院药学院中药学教研室,新乡453003 [2]新乡医学院基础医学院生物化学与分子生物学教研室,新乡453003

出　　处：《生命的化学》2021年第4期693-706,共14页Chemistry of Life

基　　金：国家自然科学基金项目(31500982);新乡医学院高层次人才引进项目(505197)。

摘　　要：蛋白质泛素化修饰是细胞内关键的翻译后调控过程,能调节蛋白质的稳定性和功能。泛素特异性肽酶(ubiquitin-specific peptidases,USPs)是去泛素化酶家族的主要成员,能够识别特定蛋白质的泛素化信号,从而使靶蛋白去泛素化,进而参与细胞增殖、分化、凋亡和迁移等多种生物学功能。USP家族的多个成员表达量改变或活性异常与肿瘤的发生与发展密切相关,USPs被用于肿瘤新型分子诊断标志物和治疗靶点。本综述对USPs在肿瘤发生发展中的作用进行阐述,为肿瘤的诊断和靶向治疗奠定基础。Protein ubiquitination is an important post-translational modification process for regulating the activity and levels of proteins in cells.The ubiquitin-specific peptidases(USPs)are the main member of the deubiquitinase family.The USPs involve in multiple biological processes including cell proliferation,differentiation,apoptosis and migration by specially recognizing and removing ubiquitin chain of target proteins.An increasing number of studies have indicated that the abnormal expression or activity of specific USPs are closely related to the occurrence and progression of human tumors,and some USPs have been used as new molecular tumor markers and therapeutic targets.Here we collect and organize most of the recent studies on the roles of USPs in tumorigenesis and progression of tumors,in order to lay the foundation for future research into the diagnosis and treatment of cancer.

关 键 词：泛素化 去泛素化酶 泛素特异性蛋白酶 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]