小胶质细胞代谢重编程在神经退行性疾病中的作用  

Role of metabolic reprograming of microglia in neurodegenerative diseases

作　　者：魏娟英 唐俊鹏 许娟 邹伟[1] WEI Juanying;TANG Junpeng;XU Juan;ZOU Wei(South China Hospital,the University of South China,Hengyang 421000,China;Hunan Children’s Hospital,Changsha 410007,China)

机构地区：[1]南华大学附属南华医院,衡阳421000 [2]湖南省儿童医院,长沙410007

出　　处：《生命的化学》2021年第4期748-755,共8页Chemistry of Life

基　　金：湖南省自然科学科卫联合基金项目(2019JJ80057);湖南省神经退行性疾病临床医学研究中心资助项目。

摘　　要：小胶质细胞作为大脑重要的固有免疫细胞,在神经免疫反应中发挥重要作用。小胶质细胞具有高度可塑性,可根据不同信号刺激表现出不同功能表型,而小胶质细胞代谢重编程可解释不同代谢途径对小胶质细胞功能表型和极化状态的调控影响。本文将重点讨论代谢重编程对小胶质细胞可塑性和功能的影响及其与神经退行性疾病之间的关系。As the important part of innate immune cells in the brain,microglia plays a significant role in the neuroimmune response.Microglia has high plasticity,which can display different functional phenotypes according to different cell signal stimulation.Nevertheless,metabolic reprogramming of microglia can explain the regulatory effects of different metabolic pathways on the functional phenotype and polarization state of microglia.This paper will emphatically discuss the effect of metabolic reprogramming on the plasticity and function of microglia and the relationship between neurodegenerative diseases and microglial metabolism reprogramming.

关 键 词：小胶质细胞 糖代谢 脂肪酸代谢 氨基酸代谢 神经退行性疾病 

分 类 号：R749.1[医药卫生—神经病学与精神病学]