光动力疗法联合声动力疗法在抗肿瘤方面的研究进展  

Research progress of photodynamic therapy combined with sonodynamic therapy in anti-tumor

作　　者：胡宇[1] 刘爱华[1] 刘蓉 HU Yu;LIU Aihua;LIU Rong(Medical College of China Three Gorges University,Yichang 443000,China;Department of Ultrasound,The First College of Clinical Medical Science,China Three Gorges University,Yichang 443000,China)

机构地区：[1]三峡大学医学院,宜昌443000 [2]三峡大学第一临床医学院超声科,宜昌443000

出　　处：《生命的化学》2021年第4期783-787,共5页Chemistry of Life

基　　金：湖北省重点实验室开放基金项目(2019KZL10)。

摘　　要：光动力疗法是一种使用光敏药物和激光活化治疗肿瘤疾病的方法。用特定波长的光辐照肿瘤部位,能使选择性聚集在肿瘤组织的光敏药物活化,引发光化学反应破坏肿瘤。然而,光动力疗法在临床上的应用却一直存在治疗深度受限的问题。本文分析了光动力疗法在临床应用中的局限性,并指出光动力疗法联合声动力疗法是一种可以克服光动力疗法治疗深度局限性的新型非侵入性治疗方法。Photodynamic therapy is a method treating tumor diseases with photosensitive drugs and laser activation.Irradiating the tumor with a specific wavelength of light can activate the photosensitive drug that selectively accumulates in the tumor tissue and trigger a photochemical reaction to destroy the tumor.However,the clinical application of photodynamic therapy always had the problem of limited treatment depth.This review analyzes the limitations of photodynamic therapy in clinical applications,and points out that photodynamic therapy combined with sonodynamic therapy is a new type of non-invasive treatment that can overcome the depth limitations of photodynamic therapy.

关 键 词：声动力疗法 光动力疗法 抗肿瘤 联合治疗 

分 类 号：R730.5[医药卫生—肿瘤]