口腔鳞状细胞癌中IL-17及IL-24表达水平及临床意义  

Expression Levels of IL-17 and IL-24 in Oral Squamous Cell Carcinoma and TheirClinical Significance

作　　者：艾敏[1] 高岚[2] AI Min;GAO Lan(People's Hospital of Puyang,Puyang,457000)

机构地区：[1]河南省濮阳市人民医院,457000 [2]河南省人民医院,450000

出　　处：《实用癌症杂志》2021年第5期719-724,共6页The Practical Journal of Cancer

摘　　要：目的探究口腔鳞状细胞癌(OSCC)中白细胞介素(IL)-17及IL-24表达水平及临床意义。方法选取61例OSCC患者作为研究组,另取73例癌前病变患者作为对照组。统计2组血清IL-17、IL-24水平及传统肿瘤标志物[细胞角蛋白19片段(Cyfra 21-1)、鳞状细胞癌抗原(SCCAg)]水平,Pearson分析血清IL-17、IL-24与临床病理特征关系,绘制受试者工作特征曲线(ROC)分析血清IL-17、IL-24诊断OSCC价值。随访1年,比较不同血清IL-17、IL-24水平1年生存率。结果研究组血清IL-17、Cyfra 21-1、SCCAg水平高于对照组,血清IL-24水平低于对照组(P<0.05)。OSCC不同分化程度、临床分期、淋巴结转移患者血清IL-17、IL-24水平比较,差异有统计学意义(P<0.05)。ROC显示,Cyfra 21-1诊断OSCC的曲线下面积(AUC)最大,诊断敏感性及特异性分别为68.85%、84.93%。根据血清IL-17、IL-24平均值分为高水平组和低水平组,KM曲线显示,IL-17高水平组生存率低于低水平组,IL-24高水平组生存率高于低水平组(P<0.05)。结论血清IL-17、IL-24水平均在OSCC患者中呈异常表达,早期检测,可为临床OSCC诊断、实施个性化治疗、评估预后提供新思路。Objective To explore the expression levels and clinical significance of interleukin(IL)-17 and IL-24 in oral squamous cell carcinoma(OSCC).Methods 61 OSCC patients were selected as the study group,and 73 patients with precancerous lesions were selected as the control group.The levels of serum IL-17,IL-24 and traditional tumor markers[cytokeratin 19 fragment(Cyfra 21-1),squamous cell carcinoma antigen(SCCAg)]of the 2 groups were counted.Pearson was used to analyze the relationship between serum IL-17,IL-24 and clinicopathological characteristics,and the receiver operating characteristic curve(ROC)was drawn to analyze the value of serum IL-17 and IL-24 in the diagnosis of OSCC.After 1-year follow-up,the 1-year survival rates of different serum IL-17 and IL-24 levels were compared.Results The serum IL-17,Cyfra 21-1,and SCCAg levels in the study group were higher than those in the control group,and the serum IL-24 levels were lower than the control group(P<0.05).There were statistically significant differences in serum IL-17 and IL-24 levels in patients with different differentiation degrees,clinical stages,and lymph node metastasis of OSCC(P<0.05).ROC showed that the area under the curve(AUC)for the diagnosis of OSCC by Cyfra 21-1 was the largest,and the diagnostic sensitivity and specificity were 68.85%and 84.93%,respectively.According to the average value of serum IL-17 and IL-24,they were divided into high-level group and low-level group.The KM curve showed that the survival rate of IL-17 high-level group was lower than that of low-level group,and the survival rate of IL-24 high-risk group was higher than that of low-risk group(P<0.05).Conclusion Serum IL-17 and IL-24 levels are abnormally expressed in OSCC patients.Early detection can provide new ideas for clinical OSCC diagnosis,implementation of personalized treatment,and prognosis assessment.

关 键 词：口腔鳞状细胞癌 白细胞介素17 白细胞介素24 细胞角蛋白19片段 鳞状细胞癌抗原 受试者工作特征曲线 

分 类 号：R739.8[医药卫生—肿瘤]