T细胞非霍奇金淋巴瘤患者的临床病理因素及其与预后的相关性  

Analysis of Clinicopathological Factors in Patients with T Cell Non-Hodgkin’sLymphoma and Its Correlation with Prognosis

作　　者：邢伟[1] XING Wei(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2021年第5期853-855,共3页The Practical Journal of Cancer

摘　　要：目的分析T细胞非霍奇金淋巴瘤患者的临床病理因素及其与预后的相关性。方法回顾性分析T细胞非霍奇金淋巴瘤患者60例临床资料,整理入选者所有基础资料与病理资料,如年龄、性别、症状、肿瘤部位、病变直径、临床分期、乳酸脱氢酶(LDH)变化及治疗情况等。随访3年,记录生存状况,并分析病理表现与预后关系。结果T细胞非霍奇金淋巴瘤发病以男性、≥60岁人群居多,初期症状表现为消化系统症状,病变部位主要为结内,病变直径大部分<10 cm,LDH升高占比较少。随访3年,60例T细胞非霍奇金淋巴瘤患者生存率为26.67%(16/60)。单因素分析显示年龄≥60岁、B组症状、病变直径≥10 cm、临床分期Ⅲ~Ⅳ期、LDH升高与预后不良有关(P<0.05),性别、病变部位则与预后无明显关系(P>0.05);Logistic回归分析:年龄≥60岁、B组症状、病变直径≥10 cm、临床分期Ⅲ~Ⅳ期、LDH升高是影响T细胞非霍奇金淋巴瘤患者预后的独立危险因素(P<0.05且OR≥1)。结论T细胞非霍奇金淋巴瘤患者临床病理表现复杂,且预后较差,年龄、症状、肿瘤直径、分期、LDH水平均与预后相关,临床需予以高度重视。Objective To analyze the clinicopathological factors of T cell non-Hodgkin's lymphoma and its correlation with prognosis.Methods The clinical data of 60 patients with T cell non-Hodgkin lymphoma were retrospectively analyzed,all basic and pathological data of the candidates,age,sex,symptoms,tumor site,lesion diameter,clinical stage,lactate dehydrogenase(LDH)changes and treatment were collected.Followed up for 3 years,and record survival,The pathological manifestations and their relationship with prognosis were analyzed.Results The majority of patients with T cell non-Hodgkin's lymphoma were men and≥aged 60,Initial symptoms are digestive symptoms,The lesion was mainly in the knot,Most of the lesions<10 cm,(b)LDH increases were relatively small;For 3 years,60 patients with T cell non-Hodgkin lymphoma had a survival rate of 26.67%(16/60);age≥60 years,B group symptoms,lesion diameter≥10 cm、clinical stage III-IV,increased LDH were associated with poor prognosis,difference was statistically significant(P<0.05);Sex,lesion location and prognosis were not significant,(b)The difference was not statistically significant(P>0.05);Logistic regression analysis:age≥60 years,B group symptoms,lesion diameter≥10 cm、clinical stage iii-iv,increased LDH were independent risk factors for prognosis in patients with non-hodgkin lymphoma of T cells(0.05 and OR≥1).Conclusion T cell non-Hodgkin's lymphoma has complicated clinicopathological findings and the prognosis is poor.Age,symptoms,tumor diameter,stage and LDH level are all related to the prognosis.

关 键 词：T细胞非霍奇金淋巴瘤 病理因素 预后 相关性 

分 类 号：R733.4[医药卫生—肿瘤]