甘油三酯葡萄糖指数与非酒精性脂肪性肝病的关联性研究  

Relationship between triglyceride-glucose index and non-alcoholic fatty liver disease

作　　者：刘奕婷[1] 王巍[1] 佟静[2] 王炳元[2] Liu Yiting;Wang Wei;Tong Jing;Wang Bingyuan(Department of Physical Examination Center,the First Affiliated Hospital,China Medical University,Shenyang 110001,China;Department of Gastroenterology,the First Affiliated Hospital,China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院体检中心,沈阳110001 [2]中国医科大学附属第一医院消化内科,沈阳110001

出　　处：《中华肝脏病杂志》2021年第5期451-455,共5页Chinese Journal of Hepatology

基　　金：国家青年自然科学基金(8170030364)。

摘　　要：目的探讨甘油三酯葡萄糖指数(TyG)与非酒精性脂肪性肝病(NAFLD)之间的关系。方法选取2019年1月至2019年12月在中国医科大学附属第一医院参加健康体检且符合条件的25535例受检者作为研究对象。采用logistic回归分析和受试者操作特征曲线分析TyG指数与NAFLD患病风险的关联及其对NAFLD的诊断价值。结果NAFLD的患病率随着TyG指数的升高而逐渐递增;在校正其他潜在影响因素后,TyG第二、三、四分位组与第一分位组相比,NAFLD患病风险的OR值(95%CI)分别为1.677(1.495~1.881),2.707(2.397~3.057)和4.049(3.482~4.710);受试者操作特征曲线分析结果显示,TyG指数诊断NAFLD的最佳临界值为6.9,曲线下面积为0.816,灵敏度和特异度分别为77.66%和70.51%,联合TyG指数和丙氨酸转氨酶水平具有更高的诊断价值。结论TyG作为一项简单方便的生物学合成指标,与NAFLD患病之间密切相关,当TyG指数≥6.9时,对NAFLD具有较高的诊断价值。Objective To explore the relationship between triglyceride-glucose index(TyG)and non-alcoholic fatty liver disease(NAFLD).Methods 25535 cases who participated in the health check-ups at the First Hospital of China Medical University from January 2019 to December 2019 were selected as the eligible subjects.Logistic regression analysis and receiver operating characteristic curve were used to analyze the relationship between TyG index and NAFLD risk and its diagnostic value for NAFLD.Results NAFLD prevalence was gradually increased with the increase of the TyG index.After adjusting for other potential influencing factors,compared with the first quarter of TyG in patient with NAFLD,the OR(95%CI)in the second,third,and fourth quarter were 1.677(1.495~1.881),2.707(2.397~3.057)and 4.049(3.482~4.710),respectively.Receiver operating characteristic curve analysis showed that the best cut-off value of TyG index for the diagnosis of NAFLD was 6.9,and the area under the curve was 0.816.The sensitivity and specificity were 77.66%and 70.51%,respectively.The combined application of TyG and ALT levels had higher diagnostic value.Conclusion TyG,as a simple and convenient biosynthetic index,is closely related to the NAFLD.In addition,when the TyG index is≥6.9,it has a high diagnostic value for NAFLD.

关 键 词：非酒精性脂肪性肝病 健康体检 甘油三酯葡萄糖指数 

分 类 号：R575.5[医药卫生—消化系统]