胆汁酸、肠道微生物与胆管癌发生和发展关系的研究进展  

Advances in research on the relationship between bile acid,gut microbiota and the occurrence and development of cholangiocarcinoma

作　　者：桑慧 李文洁 周颖[1] 朱宏[1] Sang Hui;Li Wenjie;Zhou Ying;Zhu Hong(Department of Gastroenterology,the First Affiliated Hospital With Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院消化内科,210029

出　　处：《中华肝脏病杂志》2021年第5期493-496,共4页Chinese Journal of Hepatology

基　　金：江苏省六大人才高峰(WSN-030);江苏省"333"工程项目(LGY2016010);南京市科技局项目(201715003)。

摘　　要：胆管癌是一种起源于胆管上皮的恶性肿瘤,因发病隐匿,缺乏有效的早期诊断方法,一经发现均属于晚期,预后不良。胆汁酸是胆汁的主要成分,它可通过胆汁酸受体作用于胆管细胞,在胆管癌的发生演变中起着关键作用,而肠道微生物可通过调节胆汁酸代谢参与胆管癌的发生。现主要针对胆汁酸、胆汁酸受体在胆管癌发生和发展中的作用以及肠道微生物在其中的影响进行综述。Cholangiocarcinoma is a kind of malignant tumor that originates from the bile duct epithelium.Due to its insidious nature,there is no effective early diagnosis and treatment method.Therefore,once it is detected,it is at an advanced stage and has a poor prognosis.Bile acid is the main component of bile,which acts on cholangiocytes through bile acid receptors and plays a key role in the development of cholangiocarcinoma.Gut microbiota can participate in the occurrence of cholangiocarcinoma by regulating bile acid metabolism.This review mainly focuses on the role of bile acid and bile acid receptors in the occurrence and development of cholangiocarcinoma and the impact of gut microbiota in it.

关 键 词：胆管癌 胆汁酸 胆汁酸受体 肠道微生物 

分 类 号：R735.8[医药卫生—肿瘤]