动脉自旋标记和动态磁敏感对比增强灌注成像在脑膜瘤中的对比应用  

Comparative application of arterial spin labeling and dynamic susceptibility contrast-enhanced perfusion imaging in meningiomas

作　　者：李娟[1,2] 黄玲[2] 纪宇[2] 邵纯纯[2] 苏凯 邵广瑞 LI Juan;HUANG Ling;JI Yu;SHAO Chunchun;SU Kai;SHAO Guangrui(Shandong University, Jinan 250012, P.R.China;Medical Imaging Center, The Second Hospital of Shandong University, Jinan 250033, P.R.China)

机构地区：[1]山东大学,山东济南250012 [2]山东大学第二医院医学影像中心,山东济南250033

出　　处：《医学影像学杂志》2021年第5期726-730,共5页Journal of Medical Imaging

摘　　要：目的分析比较动脉自旋标记(arterial spin labeling,ASL)和动态磁敏感对比增强(dynamic susceptibility contrast-enhanced,DSC)灌注成像技术在脑膜瘤中的临床应用价值。方法前瞻性分析41例在我院行磁共振检查的脑膜瘤患者的影像资料,除颅脑MRI常规序列外,均行ASL及DSC灌注检查,采用定量法及视觉分析法对两种灌注资料进行分析,采用Pearson线性相关分析ASL CBF和DSC的rCBF、rCBV相关性;将两种灌注方式的图像分为三个等级进行评分,用Fisher检验分析两种灌注方式图像评分的差异。结果ASL CBF与DSC rCBF之间、ASL CBF与DSC rCBV之间存在显著相关,ASL与DSC图像评分差异有统计学意义(P<0.001)。结论在评价脑膜瘤脑血流灌注方面,ASL与DSC具有相似的诊断价值,但与DSC图像相比,ASL图像磁敏感伪影明显减少,同时无需使用对比剂,可重复性好,尤其适用于多次复查患者。Objective To evaluate the clinical value of pseudo-continuous arterial spin labeling(pc-ASL)and dynamic susceptibility contrast-enhanced(DSC)perfusion imaging in meningiomas.Methods The imaging data of 41 patients with meningioma who underwent MRI examination in our hospital were analyzed prospectively.In addition to routine clinical MRI sequences,both ASL and DSC perfusion imaging were also performed on all patients.These perfusion data were first analyzed qualitatively with visual evaluation,and then quantitatively by obtaining relative cerebral blood flow(i.e.,CBF for ASL,and rCBF&rCBV for DSC).Pearson linear correlation analysis was employed to evaluate the corresponding relationship between these perfusion parameters.A 3-point scale was applied to assess the image quality of these perfusion imaging.Fisher test was also used to analyze the difference of image scores between both perfusion imaging.Results Significant correlation was separately found between CBF of ASL and rCBF of DSC,and between CBF of ASL and rCBV of DSC.However,a significant difference was observed between the image scores of both perfusion imaging(P<0.001).Conclusion ASL and DSC have shown similar diagnostic value in evaluating the cerebral blood flow perfusion of meningiomas.However,compared with DSC images,ASL images suffer significantly less susceptibility artifacts.In addition,for ASL imaging,no contrast agent is required and good reproducibility is achieved,especially being suitable of performing follow-up experiments for brain tumor patients.

关 键 词：动脉自旋标记 动态磁敏感对比增强灌注成像 脑膜瘤 磁共振成像 

分 类 号：R739.41[医药卫生—肿瘤] R445.2[医药卫生—临床医学]