氯沙坦与阿替洛尔治疗马方综合征进行性主动脉扩张效果的meta分析  

Meta-Analysis of Losartan and Atenolol in the Treatment of Progressive Aortic Dilatation in Marfan Syndrome

作　　者：张强 郑玥[2,3,4,5] 齐振昌 稂与恒 龚亦杰 宁萌[1,3,4] 高文卿 李彤 ZHANG Qiang;ZHENG Yue;QI Zhenchang;LANG Yuheng;GONG Yijie;NING Meng;GAO Wenqing;LI Tong(The Third Central Clinical College of Tianjin Medical University,Tianjin 300170,China;School of Medicine,Nankai University,Tianjin 300071,China;the Third Central Hospital of Tianjin,Tianjin 300170,China;Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Tianjin 300170,China;Institute of Hepatobiliary Disease,the Third Central Hospital of Tianjin,Tianjin 300170,China)

机构地区：[1]天津医科大学三中心临床学院,天津300170 [2]南开大学医学院,天津300071 [3]天津市第三中心医院,天津300170 [4]天津市危重疾病体外生命支持重点实验室,天津300170 [5]天津市第三中心医院肝胆疾病研究所,天津300170

出　　处：《河南医学研究》2021年第13期2305-2310,共6页Henan Medical Research

摘　　要：目的系统评价氯沙坦与阿替洛尔对马方综合征(MFS)进展性主动脉扩张的影响。方法计算机检索发表在PubMed、Medline、Embase、Web of Science和Cochrane Library数据库中所有相关研究,并进行纳入和排除。主要终点为出现主动脉主要并发症或进行心血管手术,数据使用Stata 14.0进行分析。对所有研究终点计算标准化均数差(SMD)和相应的95%置信区间(CI)。使用漏斗图评估发表偏倚。结果共纳入5篇文献进行meta分析。所有纳入的试验均为前瞻性临床试验。根据随机效应模型,氯沙坦和阿替洛尔在治疗升主动脉扩张率和主动脉根部直径方面比较,差异无统计学意义(P>0.05)。结论氯沙坦和阿替洛尔治疗MFS进展性主动脉扩张效果无明显差异,但仍需要更多研究数据支持。Objective To systematically evalute the effects of losartan and atenolol on progressive aortic dilatation in Marfan syndrome(MFS).Methods The computerized search was proceeded to identify all relevant published studies in PubMed,Medline,Embase,Web of Science and Cochrane Library databases with inclusion and exclusion criteria.The primary endpoint was major aortic complication or cardiovascular surgery,and the data were analyzed using Stata 14.0.The standardized mean difference(SMD)and the corresponding 95%confidence interval(CI)were calculated for each endpoint across all the studies.Publication bias was evaluated by a funnel plot.Results A total of 5 articles were included to meta-analysis.All included trials were prospective.There was no difference between losartan and atenolol therapy in the treatment of ascending aortic dilatation rate and aortic root diameter using the random effect model(P>0.05).Conclusion There is no difference between losartan and atenolol in the treatment of progressive aortic dilatation in MFS,but further research data are still required.

关 键 词：马方综合征 药物治疗 预后 META分析 

分 类 号：R593.2[医药卫生—内科学]