康莱特注射液联合5-氟尿嘧啶治疗晚期结直肠癌的疗效及对T细胞因子的影响研究  

Study on the efficacy of Kanglaite injection combined with 5-fluorouracil in the treatment of advancedcolorectal cancer and its influence on T cell factors

作　　者：王少慧 刘鉴文 曾志伟[1] 龙肖玉 WANG Shao-hui;LIU Jian-wen;ZENG Zhi-wei(Baiyun District People’s Hospital,Guangzhou 510310,China)

机构地区：[1]广州市白云区人民医院,510310

出　　处：《中国实用医药》2021年第15期108-110,共3页China Practical Medicine

基　　金：广州市白云区医疗卫生科技项目(项目编号:2018-YL-028)。

摘　　要：目的探讨康莱特注射液联合5-氟尿嘧啶治疗晚期结直肠癌(CRC)的临床疗效及对T细胞因子的影响。方法46例晚期结直肠癌患者,随机分为观察组与对照组,每组23例。对照组采用5-氟尿嘧啶治疗,观察组采用康莱特注射液联合5-氟尿嘧啶治疗。比较两组生活质量、肿瘤控制率、治疗后不良反应发生率及T细胞因子变化。结果对照组治疗前卡氏功能状态(KPS)评分为(64.42±3.21)分,治疗后KPS评分为(70.32±3.02)分;观察组治疗前KPS评分为(64.32±3.18)分,治疗后KPS评分为(79.65±7.23)分;治疗前,两组KPS评分比较,差异无统计学意义(P>0.05);治疗后,两组KPS评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组肿瘤控制率78.26%明显高于对照组的47.83%,差异有统计学意义(P<0.05)。两组治疗后不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组白细胞介素(IL)-2、IL-4、转化生长因子-β(TGF-β)水平比较,差异均无统计学意义(P>0.05);治疗后,观察组IL-2、IL-4水平均明显高于对照组,TGF-β水平明显低于对照组,差异有统计学意义(P<0.05)。结论康莱特注射液联合5-氟尿嘧啶治疗晚期结直肠癌效果显著,可有效提高患者生活质量,增强机体抵抗力。Objective To discuss the clinical efficacy of Kanglaite injection combined with 5-fluorouracil in the treatment of advanced colorectal cancer(CRC)and its influence on T cell factors.Methods A total of 46 patients with advanced colorectal cancer were randomly divided into observation group and control group,with 23 cases in each group.The control group was treated with 5-fluorouracil,and the observation group was treated with Kanglaite injection combined with 5-fluorouracil.The quality of life,tumor control rate,occurrence of adverse reactions after treatment,and T cell factors changes were compared between the two groups.Results In the control group,the Karnofsky performance status(KPS)score was(64.42±3.21)points before treatment,and(70.32±3.02)points after treatment;in the observation group,the KPS score was(64.32±3.18)points before treatment,and(79.65±7.23)points after treatment.Before treatment,there was no statistically significant difference in KPS score between the two groups(P>0.05).After treatment,the KPS score of the two groups were higher than those before treatment,and the observation group was higher than the control group.All the difference was statistically significant(P<0.05).The tumor control rate 78.26%of the observation group was obviously higher than 47.83%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions after treatment between the two groups(P>0.05).Before treatment,there was no statistically significant difference in interleukin(IL)-2,IL-4,transforming growth factor-β(TGF-β)between the two groups(P>0.05).After treatment,the IL-2 and IL-4 of the observation group were obviously higher than those of the control group,and TGF-βwas obviously lower than the control group.All the difference was statistically significant(P<0.05).Conclusion Combination of Kanglaite injection and 5-fluorouracil shows remarkable effect on advanced colorectal cancer,and it can effectively improve the q

关 键 词：康莱特注射液 5-氟尿嘧啶 晚期结直肠癌 T细胞因子 

分 类 号：R735.34[医药卫生—肿瘤]