肠黏液屏障:从基础到临床  

Intestinal Mucus Barrier:From Basic Research to Clinical Practice

作　　者：熊艺琳 宋军 侯晓华[1] XIONG Yilin;SONG Jun;HOU Xiaohua(Division of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,430022)

机构地区：[1]华中科技大学同济医学院附属协和医院消化内科,430022

出　　处：《胃肠病学》2020年第11期682-686,共5页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(81670488,81873553)。

摘　　要：肠道黏液屏障是由黏蛋白、水、抗菌肽等组成的凝胶网状结构,是肠腔抵御病原体的第一道防线,也是共生菌群生存、繁殖的重要环境。黏蛋白主要由肠道杯状细胞合成、分泌,在不同肠段形成结构不同的黏液层,其过程受多种因素调控。目前越来越多研究表明,黏液屏障除与肠道感染、炎症性肠病、肠道肿瘤等各种肠道疾病密切相关外,还参与某些肠外疾病如急性胰腺炎、非酒精性脂肪性肝病的发生、发展,未来可能成为各种相关疾病治疗的新靶点。Intestinal mucus barrier is a gel network composed of mucin,water and antimicrobial peptides.It is the first line defense of host against intestinal pathogens,and is also important for the survival and proliferation of symbiotic bacteria.Mucins are mainly synthesized and secreted by goblet cells of intestine,forming different structures in different intestinal segments.Nowadays more and more studies have shown that the mucus barrier is not only closely related to intestinal infection,inflammatory bowel disease,intestinal tumor and other intestinal diseases,but also involved in the occurrence and development of some extraintestinal diseases,such as acute pancreatitis,non-alcoholic fatty liver disease,which may become a new target for the treatment of various related diseases in the future.

关 键 词：黏液屏障 杯状细胞 肠疾病 肠外疾病 黏蛋白类 

分 类 号：R57[医药卫生—消化系统]