炎症性肠病发病机制和诊疗研究现状:miRNAs与肠道免疫和屏障功能  

Current Research Status of Pathogenesis,Diagnosis and Treatment of Inflammatory Bowel Disease:MiRNAs With Intestinal Immunity and Barrier Function

作　　者：李宝悦 卜祥点 陈文轩 马娜[1] 张目涵 冯百岁[1] LI Baoyue;BU Xiangdian;CHEN Wenxuan;MA Na;ZHANG Muhan;FENG Baisui(Department of Gastroenterology, the Second Affiliated Hospital of Zhengzhou University, Zhengzhou ,450014)

机构地区：[1]郑州大学第二附属医院消化内科,450014

出　　处：《胃肠病学》2020年第11期687-691,共5页Chinese Journal of Gastroenterology

基　　金：河南省医学科技攻关计划省部共建项目(SBGJ2018042);河南省卫生计生科技创新型人才“51282”工程(豫卫科[2016]32号);河南省自然科学基金(162300410268);河南省医学科技攻关计划联合共建项目(2018020164);郑州大学前沿交叉研究专项项目(32410243)。

摘　　要：微RNAs(miRNAs)是一组由基因组编码的长度约22个核苷酸残基的短链非编码RNA,可与目标mRNA的3’-非翻译区(3’-UTR)结合,在转录后水平上抑制目标基因的表达。随着对miRNAs研究的增加,发现miRNAs在炎症性肠病(IBD)的发病中可调节免疫细胞的分化和分泌、影响肠黏膜屏障功能和调节肠道菌群的构成,并可作为IBD诊断过程中重要的生物学标志物。本文从肠道免疫和屏障功能两方面出发,对miRNAs在IBD发病机制中的作用作一综述。MicroRNAs(miRNAs)are a group of short non-coding RNAs consisting of about 22 nucleotides that downregulate gene expression at posttranscriptional level through binding to the 3’-untranslated region(3’-UTR)of target mRNAs.With the increase in research about miRNAs,it is found that miRNAs could modulate the differentiation and secretion of immunocytes as well as the function of intestinal mucosal barrier.Besides,miRNAs could regulate the composition of intestinal microbiome,and could be used as crucial biomarkers for the diagnosis of inflammatory bowel disease(IBD).In this paper,the roles of miRNAs in the pathogenesis of IBD were reviewed through intestinal immunity and barrier function.

关 键 词：炎症性肠病 微RNAS 促炎细胞因子 免疫细胞 肠黏膜屏障 

分 类 号：R73[医药卫生—肿瘤]