组蛋白和TLRs 在静脉血栓栓塞性疾病中的作用机制  

The Mechanism of Histones and TLRs in Venous Thrombotic Diseases

作　　者：吴婕[1] 刘珺[1] 张燕[1] 任莉[1] 党彦丽 WU Jie;LIU Jun;ZHANG Yan;REN Li;DANG Yan-li(Dept.of Obstetrics,The First People’s Hospital of Yunnan Province,The Affiliated Hospital of Kunming University of Science and Technology,Kunming Yunnan 650032,China)

机构地区：[1]云南省第一人民医院/昆明理工大学附属医院产科,云南昆明650032

出　　处：《昆明医科大学学报》2021年第5期165-169,共5页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82060608);云南省卫生健康委员会医学领军人才基金资助项目(L-2018006)。

摘　　要：近年来随着产科高危妊娠的增加及诊断技术的提高,临床对妊娠合并静脉血栓性疾病的关注度逐年增加,尽管已识别出诱发深静脉血栓的各种危险因素,但血栓形成的机制尚不完全清楚。研究表明组蛋白在静脉血栓疾病中有着重要作用,通过TLRs或炎症通路激发炎症,促发血栓形成。旨在对组蛋白通过TLRs激发炎症诱发静脉血栓性疾病作一概述,为以后产科静脉血栓性疾病的预防和治疗提供新的突破点。In recent years,due to the increase of high-risk pregnancies in obstetrics and the improvement of diagnostic techniques,clinical attention to pregnancy complicated with venous thrombotic diseases is increasing from year to year.Although various risk factors that induce deep vein thrombosis have been identified,the mechanism of thrombosis is not yet completely clear.Studies have demonstrated that histones play a key role in venous thrombotic diseases,mediating the production of thrombus through inflammatory pathways or TLRs that activate inflammation.This article aims to provide an overview of histone-induced venous thrombotic diseases through TLRs to stimulate inflammation,and provide a new breakthrough point for the prevention and treatment of obstetric venous thrombotic diseases in the future.

关 键 词：组蛋白 TLRS 静脉血栓性疾病 

分 类 号：R543.6[医药卫生—心血管疾病]