无水乙醇经皮穿刺联合肝动脉栓塞术治疗原发性肝癌的临床效果观察  

Clinical Effect of Percutaneous Ethanol Puncture Combined with Transcatheter Arterial Embolization in Treatment of Primary Liver Cancer

作　　者：王福海 陈明 梁俏玲[1] WANG Fuhai;CHEN Ming;LIANG Qiaoling(People’s Hospital of Huangmei County,Huangmei 435500,China;不详)

机构地区：[1]黄梅县人民医院,湖北黄梅435500

出　　处：《中外医学研究》2021年第14期45-47,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究无水乙醇经皮穿刺联合肝动脉栓塞术治疗原发性肝癌的临床效果。方法:选取2018年5月-2020年5月笔者所在医院收治的82例原发性肝癌患者为研究对象,随机分为观察组和对照组,各41例。对照组给予肝动脉栓塞术治疗,观察组在此基础上联合无水乙醇经皮穿刺治疗。对两组临床疗效、肿瘤标志物水平、肝功能指标、不良反应发生率等进行统计对比。结果:观察组客观缓解率(ORR)、疾病控制率(DCR)分别为69.29%、78.05%,均高于对照组的46.34%、56.10%,差异均有统计学意义(P<0.05)。观察组甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原199(CA199)水平均低于对照组,谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)水平均低于对照组,差异均有统计学意义(P<0.05)。治疗期间观察组、对照组不良反应发生率分别为19.51%(8/41)、12.20%(5/41),差异无统计学意义(P>0.05)。结论:无水乙醇经皮经肝穿刺联合肝动脉栓塞术治疗对原发性肝癌效果显著,能够提高疾病缓解率和控制率,改善肝功能,降低肿瘤标志物水平,治疗安全性良好。Objective:To study the clinical efficacy of percutaneous ethanol puncture combined with transcatheter arterial embolization in treatment of primary liver cancer and the influence of tumor markers and liver function indexes.Method:A total of 82 patients with primary liver cancer admitted to our hospital from May 2018 to May 2020 were selected as the research subjects and randomly divided into the observation group and the control group,41 patients in each group.The control group was treated with hepatic artery embolization,and the observation group was treated with percutaneous puncture combined with anhydrous ethanol.Clinical efficacy,level of tumor markers,liver function indexes and incidence of adverse reactions were statistically compared between the two groups.Result:The objective response rate(ORR)and disease control rate(DCR)in the observation group were 69.29%and 78.05%,respectively,which were higher than 46.34%and 56.10%in the control group,the differences were statistically significant(P<0.05).The levels of alpha-fetoprotein(AFP),carcinoembryonic antigen(CEA)and carbohydrate antigen 199(CA199)in the observation group were lower than those in the control group,and the levels of alanine aminotransferase(ALT),glutamicoxalacetic transaminase(AST)and total bilirubin(TBIL)in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of ADR in the observation group and the control group was 19.51%(8/41)and 12.20%(5/41),respectively,and the difference was not statistically significant(P>0.05).Conclusion:Percutaneous transhepatic puncture with anhydrous ethanol combined with hepatic artery embolization has a significant therapeutic effect on primary liver cancer,which can improve the remission rate and control rate of patients,improve the liver function of patients,reduce the level of tumor markers in patients,and the treatment safety is good.

关 键 词：原发性肝癌 肝动脉栓塞术 无水乙醇肝穿刺 临床疗效 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]