超敏C反应蛋白、同型半胱氨酸、总胆红素、尿酸水平与复发性脑梗死的相关性分析  

Correlation Analysis of High Sensitivity C-reactive Protein,Homocysteine,Total Bilirubin,Uric Acid Levels and Recurrent Cerebral Infarction

作　　者：梁蔚蔚[1] 李晓波[1] 谢卓君[1] LIANG Weiwei;LI Xiaobo;XIE Zhuojun(The First People’s Hospital of Yunnan Province,Kunming 650032,China;不详)

机构地区：[1]云南省第一人民医院,云南昆明650032

出　　处：《中外医学研究》2021年第14期57-60,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨复发性脑梗死患者血清中超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)、同型半胱氨酸(homocysteine,Hcy)、总胆红素(total bilirubin,TBIL)、尿酸(uric acid,UA)水平及临床意义。方法:选取2017年1月-2019年10月笔者所在医院收治的复发性脑梗死及初发脑梗死患者各80例,同时选取同期入院的健康检查者80例作为对照组,采集临床资料、比较三组hs-CRP、Hcy、TBIL、UA水平及差异,研究hs-CRP、Hcy、TBIL、UA水平与复发性脑梗死的相关性。结果:(1)三组间性别、吸烟史占比、总胆固醇、低密度胆固醇水平对比差异无统计学意义(P>0.05)。复发组中高血压、糖尿病的比例,以及年龄、入院血压、空腹血糖水平均高于初发组,差异均有统计学意义(P<0.05);复发组及初发组中高血压、糖尿病、冠心病、房颤、不稳定斑块的比例,以及年龄、入院收缩压、空腹血糖水平均高于对照组,差异均有统计学意义(P<0.05),且初发组糖化血红蛋白、甘油三酯水平高于对照组,差异有统计学意义(P<0.05)。(2)初发组和复发组血清hs-CRP、Hcy浓度均高于对照组,且复发组hs-CRP、Hcy浓度、TBIL水平均高于初发组,差异均有统计学意义(P<0.05);初发组UA水平高于对照组,差异有统计学意义(P<0.05),复发组TBIL、UA浓度与对照组比较,差异无统计学意义(P>0.05)。(3)逐步非条件Logistic分析结果显示,收缩压、年龄、空腹血糖、hs-CRP、Hcy是影响脑梗死复发的危险因素(P<0.05)。结论:hs-CRP、Hcy的水平影响脑梗死的发生及复发,其浓度随脑梗死的复发而升高;TBIL水平升高可能与脑梗死复发有关;高尿酸血症可能促进脑梗死的发生,但急性期尿酸水平尚不能预测脑梗死的复发。Objective:To investigate the serum levels of high sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),total bilirubin(TBIL)and uric acid(UA)in patients with recurrent cerebral infarction(RCI).Method:A total of 80 patients with recurrent cerebral infarction and 80 patients with primary cerebral infarction admitted to our hospital from January 2017 to October 2019 were selected,and 80 health examinees admitted in the same period were selected as the control group.Clinical data were collected and the levels of hs-CRP,Hcy,TBIL and UA in the three groups and their differences were compared.The correlation between hs-CRP,Hcy,TBIL,UA and recurrent cerebral infarction was studied.Result:(1)There were no significant differences in gender,smoking history,total cholesterol and low-density lipoprotein cholesterol among the three groups(P>0.05),the proportions of hypertension and diabetes,age,admission blood pressure and fasting blood glucose in the relapse group were higher than those in the primary group,the differences were statistically significant(P<0.05),the proportions of hypertension,diabetes,coronary heart disease,atrial fibrillation and unstable plaques,age,admission systolic blood pressure and fasting blood glucose in the relapse group were higher than those in the control group,the differences were statistically significant(P<0.05),and the levels of glycosylated hemoglobin and total cholesterol in the primary group were higher than those in control group,the difference was statistically significant(P<0.05).(2)The serum hs-CRP and Hcy concentration in the primary and relapse group were higher than those in the control group,and the levels of hs-CRP,Hcy and TBIL in the relapse group were higher than those in the primary group,the differences were statistically significant(P<0.05),the UA level in the primary group was higher than that in control group,the difference was statistically significant(P<0.05),there was no significant difference in TBIL and UA concentrations between the relapse group and the control gr

关 键 词：复发性脑梗死 超敏C反应蛋白 同型半胱氨酸 总胆红素 尿酸 

分 类 号：R743.33[医药卫生—神经病学与精神病学]